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A Clinical Trial of MK-7262 and Enlicitide in Participants With High Lipoprotein(a) (MK-7262-004)
Sponsor: Merck Sharp & Dohme LLC
Summary
Researchers designed a trial medicine called MK-7262 to lower levels of Lp(a) in the blood. Researchers want to learn about giving MK-7262 with another trial medicine called enlicitide (also known as MK-0616 or enlicitide decanoate). Enlicitide is in a group of medicines that lower the amount of low-density lipoprotein cholesterol (LDL-C). The goals of this trial are to evaluate: * if MK-7262 and enlicitide taken together work better than placebo at lowering Lp(a) and LDL-C levels in the blood * if MK-7262 alone works better than placebo at lowering Lp(a) levels in the blood * the safety and tolerability of taking MK-7262 and enlicitide alone and together
Official title: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-7262 as Monotherapy and When Coadministered With Enlicitide Decanoate in Adults With Elevated Lipoprotein(a)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
750
Start Date
2026-06-30
Completion Date
2027-10-12
Last Updated
2026-10-01
Healthy Volunteers
No
Conditions
Interventions
MK-7262
Oral Coated Tablet
Enlicitide
Oral Coated Tablet
Placebo for MK-7262
Oral Coated Tablet
Placebo for enlicitide
Oral Coated Tablet
Locations (70)
Advanced Cardiovascular - Alexander City ( Site 0158)
Alexander City, Alabama, United States
AMR Clinical Mobile ( Site 0149)
Mobile, Alabama, United States
National Heart Institute ( Site 0113)
Beverly Hills, California, United States
Headlands Research CTR Lincoln ( Site 0127)
Lincoln, California, United States
Chase Medical Research, LLC ( Site 0163)
Waterbury, Connecticut, United States
Soffer Health Institute ( Site 0123)
Hollywood, Florida, United States
Westside Center for Clinical Research ( Site 0161)
Jacksonville, Florida, United States
Inpatient Research Clinic ( Site 0110)
Miami Lakes, Florida, United States
Clinical Research Trials of Florida ( Site 0101)
Tampa, Florida, United States
Conquest Research LLC ( Site 0140)
Winter Park, Florida, United States
Flourish Research - Bowie ( Site 0106)
Bowie, Maryland, United States
Velocity Clinical Research Rockville ( Site 0146)
Rockville, Maryland, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division ( Site 0132)
Troy, Michigan, United States
Minneapolis Heart Institute - Minneapolis ( Site 0130)
Minneapolis, Minnesota, United States
Montana Medical Research, Inc. ( Site 0156)
Missoula, Montana, United States
New Mexico Clinical Research & Osteoporosis Center ( Site 0119)
Albuquerque, New Mexico, United States
Laurelton Heart Specialist PC ( Site 0155)
Rosedale, New York, United States
Velocity Clinical Research, Durham ( Site 0145)
Durham, North Carolina, United States
Remington-Davis, Inc. ( Site 0107)
Columbus, Ohio, United States
Holston Medical Group ( Site 0117)
Kingsport, Tennessee, United States
Center for Cardiometabolic Disease Prevention/Baylor College of Medicine ( Site 0154)
Houston, Texas, United States
DM Clinical Research ( Site 0115)
Tomball, Texas, United States
Carient Heart & Vascular - Manassas ( Site 0165)
Manassas, Virginia, United States
Rainier Clinical Research Center ( Site 0116)
Renton, Washington, United States
North York Diagnostic and Cardiac Centre ( Site 0203)
North York, Ontario, Canada
Clinique des Maladies Lipidiques de Quebec ( Site 0201)
Québec, Quebec, Canada
Salud SURA Industriales ( Site 0405)
Medellín, Antioquia, Colombia
Clinica de la Costa S.A.S ( Site 0404)
Barranquilla, Atlántico, Colombia
Solano & Terront Servicios Medicos - UNIENDO SAS ( Site 0402)
Bogota, Cundinamarca, Colombia
IMAT S.A.S ( Site 0400)
Montería, Departamento de Córdoba, Colombia
Regionshospitalet Viborg ( Site 0507)
Viborg, Central Jutland, Denmark
Sanos Clinic - Nordjylland ( Site 0502)
Gandrup, North Denmark, Denmark
Esbjerg sygehus, Syddansk Universitetshospital ( Site 0505)
Esbjerg, Region Syddanmark, Denmark
OUH Svendborg Sygehus ( Site 0500)
Svendborg, Region Syddanmark, Denmark
Klinikum Konstanz ( Site 0723)
Konstanz, Baden-Wurttemberg, Germany
Deutsches Herzzentrum Muenchen ( Site 0717)
Munich, Bavaria, Germany
Ambulantes Herzzentrum Kassel ( Site 0721)
Kassel, Hesse, Germany
Dedicated Research Site FutureMeds ( Site 0719)
Offenbach, Hesse, Germany
Studienzentrum Brinkum - Torsten Drescher & Dr. Lars Pohlmeier ( Site 0712)
Stuhr, Lower Saxony, Germany
Universitaetsklinikum Carl Gustav Carus, Technische Universitaet Dresden' ( Site 0713)
Dresden, Saxony, Germany
zibp GmbH ( Site 0716)
Berlin, Germany
FutureMeds GmbH ( Site 0718)
Berlin, Germany
Charite Universitätsmedizin Berlin Campus Benjamin Franklin ( Site 0714)
Berlin, Germany
Medical Corporation Heishinkai OCROM Clinic ( Site 2403)
Suita, Osaka, Japan
Kumanomae Nishimura Naika Clinic ( Site 2407)
Arakawa City, Tokyo, Japan
Minamino Cardiovascular Hospital ( Site 2406)
Hachiōji, Tokyo, Japan
Kato Clinic of Internal Medicine ( Site 2402)
Katsushika-ku, Tokyo, Japan
Swing Nozaki Clinic ( Site 2405)
Musashino, Tokyo, Japan
Medical Corporation Heishinkai ToCROM Clinic ( Site 2404)
Shinjuku, Tokyo, Japan
Medical Corporation Hakuaikai Wellness Tenjin Clinic ( Site 2400)
Fukuoka, Japan
Midori Clinic ( Site 2401)
Nagasaki, Japan
National Hospital Organization Osaka National Hospital ( Site 2408)
Osaka, Japan
Ziekenhuis Gelderse Vallei ( Site 1106)
Ede, Gelderland, Netherlands
Ziekenhuis St. Jansdal ( Site 1113)
Harderwijk, Gelderland, Netherlands
Bravis Ziekenhuis, locatie Roosendaal ( Site 1102)
Roosendaal, North Brabant, Netherlands
Noordwest Ziekenhuisgroep ( Site 1110)
Alkmaar, North Holland, Netherlands
Antonius Ziekenhuis, locatie D&A Research and Genetics ( Site 1103)
Sneek, Provincie Friesland, Netherlands
Albert Schweitzer Ziekenhuis, locatie Dordwijk ( Site 1101)
Dordrecht, South Holland, Netherlands
Martini Ziekenhuis ( Site 1108)
Groningen, Netherlands
Hospital San Rafael - La Coruña ( Site 1402)
A Coruña, La Coruna, Spain
Vithas Hospital Sevilla ( Site 1401)
Castilleja de la Cuesta, Sevilla, Spain
Hospital Universitari Vall d Hebron ( Site 1403)
Barcelona, Spain
Hospital Clinic de Barcelona ( Site 1419)
Barcelona, Spain
Hospital Viamed Santa Elena ( Site 1422)
Madrid, Spain
Hospital Universitario La Paz ( Site 1405)
Madrid, Spain
Nuevas Tecnologías en D y E - Sevillaocío ( Site 1412)
Seville, Spain
University Hospital Basel ( Site 1701)
Basel, Canton of Basel-City, Switzerland
HOCH Health Ostschweiz ( Site 1703)
Sankt Gallen, Canton of St. Gallen, Switzerland
Hopitaux Universitaires (Geneve) ( Site 1704)
Geneva, Switzerland
Luzerner Kantonsspital ( Site 1702)
Lucerne, Switzerland