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A Clinical Trial of MK-7262 and Enlicitide in Participants With High Lipoprotein(a) (MK-7262-004)
Sponsor: Merck Sharp & Dohme LLC
Summary
Researchers designed a trial medicine called MK-7262 to lower levels of Lp(a) in the blood. Researchers want to learn about giving MK-7262 with another trial medicine called enlicitide (also known as MK-0616 or enlicitide decanoate). Enlicitide is in a group of medicines that lower the amount of low-density lipoprotein cholesterol (LDL-C). The goals of this trial are to evaluate: * if MK-7262 and enlicitide taken together work better than placebo at lowering Lp(a) and LDL-C levels in the blood * if MK-7262 alone works better than placebo at lowering Lp(a) levels in the blood * the safety and tolerability of taking MK-7262 and enlicitide alone and together
Official title: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-7262 as Monotherapy and When Coadministered With Enlicitide Decanoate in Adults With Elevated Lipoprotein(a)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
750
Start Date
2026-06-30
Completion Date
2027-10-12
Last Updated
2026-08-17
Healthy Volunteers
No
Conditions
Interventions
MK-7262
Oral Coated Tablet
Enlicitide
Oral Coated Tablet
Placebo for MK-7262
Oral Coated Tablet
Placebo for enlicitide
Oral Coated Tablet
Locations (23)
Advanced Cardiovascular - Alexander City ( Site 0158)
Alexander City, Alabama, United States
AMR Clinical Mobile ( Site 0149)
Mobile, Alabama, United States
National Heart Institute ( Site 0113)
Beverly Hills, California, United States
Headlands Research CTR Lincoln ( Site 0127)
Lincoln, California, United States
Chase Medical Research, LLC ( Site 0163)
Waterbury, Connecticut, United States
Soffer Health Institute ( Site 0123)
Hollywood, Florida, United States
Westside Center for Clinical Research ( Site 0161)
Jacksonville, Florida, United States
Inpatient Research Clinic ( Site 0110)
Miami Lakes, Florida, United States
Clinical Research Trials of Florida ( Site 0101)
Tampa, Florida, United States
Conquest Research LLC ( Site 0140)
Winter Park, Florida, United States
Flourish Research - Bowie ( Site 0106)
Bowie, Maryland, United States
Velocity Clinical Research Rockville ( Site 0146)
Rockville, Maryland, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division ( Site 0132)
Troy, Michigan, United States
Montana Medical Research, Inc. ( Site 0156)
Missoula, Montana, United States
New Mexico Clinical Research & Osteoporosis Center ( Site 0119)
Albuquerque, New Mexico, United States
Laurelton Heart Specialist PC ( Site 0155)
Rosedale, New York, United States
Velocity Clinical Research, Durham ( Site 0145)
Durham, North Carolina, United States
Remington-Davis, Inc. ( Site 0107)
Columbus, Ohio, United States
Holston Medical Group ( Site 0117)
Kingsport, Tennessee, United States
DM Clinical Research ( Site 0115)
Tomball, Texas, United States
Carient Heart & Vascular - Manassas ( Site 0165)
Manassas, Virginia, United States
Rainier Clinical Research Center ( Site 0116)
Renton, Washington, United States
Minamino Cardiovascular Hospital ( Site 2406)
Hachiōji, Tokyo, Japan