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Higher Radiation Dose to the Tumor May Help Avoid Surgery in Rectal Cancer Patients
Sponsor: Claudia Schuurhuizen
Summary
The goal of this prospective study is to evaluate if a higher radiation dose to the tumor can increase the organ preservation rate in non-locally advanced rectal cancer.
Official title: REctal Organ Preservation With a BOost Approach Using CBCT-based Online Adaptive radioTherapy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
25
Start Date
2026-01-27
Completion Date
2030-08-01
Last Updated
2026-06-01
Healthy Volunteers
No
Conditions
Interventions
Simultaneous integrated boost to the tumor and positive mesorectal lymph nodes
Addition of a simultaneous integrated boost (SIB) to the standard chemoradiotherapy (CRT) scheme of 2.0 Gy to the mesorectum. The radiotherapy scheme consists of 25 fractions, delivering 2.0 Gy per fraction to the mesorectum and 2.4 Gy per fraction to the tumor and positive mesorectal lymph nodes.
Locations (1)
Erasmus MC
Rotterdam, South Holland, Netherlands