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RECRUITING
NCT07618676
NA

The 50:50 Nitrous Oxide vs 2% Lidocaine Challenge

Sponsor: Institute for Oncology and Radiology of Serbia

View on ClinicalTrials.gov

Summary

The main goal of the project is to assess pain levels and patient comfort during the administration of a 50:50 Nitrous Oxide/Oxygen gas mixture, in comparison to the same parameters under the standard method used at our institution, which includes injecting a local anaesthetic at the site of planned puncture for central venous catheterisation.

Official title: The 50:50 Nitrous Oxide Challenge: A Prospective Randomised Trial - Needle, Meet Your Match

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

62

Start Date

2025-06-06

Completion Date

2026-07-01

Last Updated

2026-06-01

Healthy Volunteers

Yes

Interventions

DRUG

Nitrous Oxide-Oxygen

After placing the patient in the appropriate supination + Trendelenburg position, the operative field (neck and subclavian region) is prepared using antiseptic measures.Five minutes before needle insertion, a mask connected to a 50:50 Nitrous Oxide/Oxygen cylinder with a flow rate of 6 liters per minute is placed on the patient's face and held by the patient. The mask has a valve that opens only when the patient creates negative pressure during inhalation.The patient is instructed to breathe spontaneously; the mask is removed once the catheter is inserted into the target vein or after cessation of painful stimulation.

DRUG

Lidocaine 2% Injectable Solution

After placing the patient in the appropriate supination + Trendelenburg position, the operative field (neck and subclavian region) is prepared using antiseptic measures. Then, under ultrasound control, the most favorable central vein for puncture is determined (v. jugularis interna or v. subclavia) and a 25-gauge needle is used to infiltrate the skin and subcutaneous tissue above the selected vein with local anesthetic. Five minutes after infiltration, puncture of the selected vein is performed using the Seldinger technique. Continuous communication with the patient is maintained throughout the procedure.

Locations (1)

Institute for Oncology and Radiology of Serbia

Belgrade, Savski Venac, Serbia