Clinical Research Directory

Inclusion Criteria: 1. 18 years or older at the time of informed consent 2. Have a diseased native or prosthetic aortic valve and a damaged or diseased ascending aorta that requires aortic valved conduit replacement surgery with the KONECT RESILIA AVC 3. Provide written informed consent 4. Willing to follow protocol requirements Exclusion Criteria: 1. Active endocarditis or endocarditis within 3 months prior to the study index procedure 2. Emergency procedure 3. Stage 4 renal disease (estimated glomerular filtration rate \[eGFR\] \<30 excluded) or requiring dialysis 4. Less than 2-year life expectancy due to non-cardiovascular life-threatening disease in the opinion of the study investigator 5. High predicted risk of mortality prior to the procedure: Society of Thoracic Surgeons Predicted Risk of Mortality (STS-PROM) ≥8%