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GLP-1 RA Cessation and Gastric Ultrasound Findings
Sponsor: Wonkwang University Hospital
Summary
This prospective observational study will evaluate the association between the time interval since the last dose of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and residual gastric contents before elective surgery. Adult patients receiving GLP-1 RAs and scheduled for elective non-cardiac surgery under general anesthesia will undergo preoperative point-of-care gastric ultrasound. The study will assess whether longer GLP-1 RA cessation intervals are associated with lower ultrasound-estimated gastric volume and a lower frequency of high-risk gastric contents. Body mass index will also be evaluated as a potential modifier of this association.
Official title: Time-dependent Association Between Cessation of Glucagon-like Peptide-1 Receptor Agonists and Residual Gastric Contents Assessed by Point-of-care Gastric Ultrasound: a Prospective Observational Study
Key Details
Gender
All
Age Range
19 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
186
Start Date
2026-02-04
Completion Date
2026-05-20
Last Updated
2026-06-05
Healthy Volunteers
Not specified
Interventions
GLP-1 RA Cessation Interval
Observed exposure defined as the number of days between the participant's last glucagon-like peptide-1 receptor agonist dose and elective surgery. Participants were categorized according to time since last dose: 3 days or less, 4 to 7 days, and 8 days or more. No GLP-1 receptor agonist was assigned, administered, continued, or discontinued by the study protocol; medication management followed usual clinical care.
Locations (1)
Wonkwang University School of Medicine Hospital
Iksan, Jeonbuk-do, South Korea