Clinical Research Directory
Browse clinical research sites, groups, and studies.
AI-Guided Intensified Follow-up After Surgery for Acute Type A Aortic Dissection
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Summary
This multicenter, prospective, randomized controlled trial will evaluate whether an artificial intelligence (AI) multimodal prediction model-guided intensified follow-up strategy improves 1-year outcomes after surgery for acute Stanford type A aortic dissection. Eligible adult patients who have undergone open surgical repair or open plus endovascular/hybrid repair and are clinically stable to enter the postoperative follow-up phase will be randomized 1:1 to usual postoperative follow-up or AI-guided intensified follow-up. The AI-guided arm will receive usual follow-up plus an AI-generated risk stratification report for 1-year mortality and adverse aortic remodeling. Higher-risk patients may receive more frequent follow-up, prioritized CTA review, multidisciplinary assessment, and targeted management reminders. The primary outcome is all-cause mortality through postoperative day 365. Key secondary outcomes include aortic reintervention, adverse aortic remodeling, and ICU readmission within 1 year.
Official title: Artificial Intelligence Multimodal Prediction Model-Guided Intensified Follow-up Strategy for 1-Year Outcomes After Surgery for Acute Type A Aortic Dissection: A Multicenter Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1314
Start Date
2026-12-01
Completion Date
2029-12-01
Last Updated
2026-06-03
Healthy Volunteers
No
Conditions
Interventions
Usual Postoperative Follow-up Strategy
Routine postoperative surveillance and management after acute type A aortic dissection repair according to each center's standard clinical practice.
AI Prediction Model-Guided Intensified Follow-up Strategy
Use of a previously developed AI multimodal prediction model to generate risk stratification for postoperative 1-year mortality and adverse aortic remodeling, triggering protocolized intensified follow-up actions when indicated.