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Non-Invasive Malignancy Classifiers Using Blood-Biomarkers for Lung Nodule Evaluation
Sponsor: Herlev and Gentofte Hospital
Summary
The goal of the NIMBLE study is to evaluate blood-based biomarkers for lung cancer risk prediction in patients referred with a lung nodule. Each blood biomarker will be evaluated for descriminating malignant from benign lung nodules alone and in combination with other blood biomarkers, patient characteristics and radiological features.
Official title: NIMBLE | Non-Invasive Malignancy Classifiers Using Blood-Biomarkers for Lung Nodule Evaluation
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
1800
Start Date
2024-05-22
Completion Date
2028-02-01
Last Updated
2026-06-03
Healthy Volunteers
Yes
Interventions
Blood tests
Standard blood tests, Novel protein tumor markers specifically targeting lung cancer, Epigenetic smoking marker (AHRR methylation), Combined fragmentome, mutational and methylome analysis of cell-free tumor DNA
Locations (1)
Gentofte Hospital
Gentofte Municipality, Denmark