Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Phase III Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With CKD Stage 3b and 4 (BalanceD-CKD)
Sponsor: AstraZeneca
Summary
The purpose of this study is to evaluate the efficacy, safety and tolerability of balcinrenone in fixed combination with dapagliflozin, compared with dapagliflozin, in patients with CKD Stage 3b and 4 (eGFR ≥ 15 to \< 45 mL/min/1.73 m2) administered orally once daily in addition to SoC. This is a population with high unmet medical need and an increased risk of CKD progression, who are frequently excluded from interventional trials.
Official title: A Phase III, Randomised, Double-blind, Study to Evaluate the Effect of Balcinrenone/Dapagliflozin Compared With Dapagliflozin on Renal and Cardiovascular Outcomes in Patients With Chronic Kidney Disease (Stage 3b and 4)
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
2800
Start Date
2026-09-01
Completion Date
2030-07-01
Last Updated
2026-09-24
Healthy Volunteers
No
Conditions
Interventions
Balcinrenone/dapagliflozin
balcinrenone/dapagliflozin 15 mg/10 mg
Dapagliflozin
dapagliflozin 10 mg
Placebo matching Dapagliflozin
matching placebo for dapagliflozin 10 mg
Placebo matching balcinrenone/dapagliflozin
matching placebo for balcinrenone/dapagliflozin
Locations (478)
Research Site
Huntsville, Alabama, United States
Research Site
Surprise, Arizona, United States
Research Site
Tempe, Arizona, United States
Research Site
Little Rock, Arkansas, United States
Research Site
Concord, California, United States
Research Site
Daly City, California, United States
Research Site
Fremont, California, United States
Research Site
Huntington Park, California, United States
Research Site
Lancaster, California, United States
Research Site
Lynwood, California, United States
Research Site
Northridge, California, United States
Research Site
Palo Alto, California, United States
Research Site
Pomona, California, United States
Research Site
Riverside, California, United States
Research Site
San Dimas, California, United States
Research Site
Tarzana, California, United States
Research Site
Washington D.C., District of Columbia, United States
Research Site
Boca Raton, Florida, United States
Research Site
Fort Lauderdale, Florida, United States
Research Site
Gainesville, Florida, United States
Research Site
Hollywood, Florida, United States
Research Site
Jacksonville Beach, Florida, United States
Research Site
Lakeland, Florida, United States
Research Site
Melbourne, Florida, United States
Research Site
Orlando, Florida, United States
Research Site
Port Charlotte, Florida, United States
Research Site
Riverview, Florida, United States
Research Site
Weston, Florida, United States
Research Site
Brunswick, Georgia, United States
Research Site
East Point, Georgia, United States
Research Site
Macon, Georgia, United States
Research Site
Savannah, Georgia, United States
Research Site
Oak Brook, Illinois, United States
Research Site
Rockford, Illinois, United States
Research Site
Iowa City, Iowa, United States
Research Site
Wichita, Kansas, United States
Research Site
Louisville, Kentucky, United States
Research Site
Ann Arbor, Michigan, United States
Research Site
Saint Joseph, Michigan, United States
Research Site
Mankato, Minnesota, United States
Research Site
Kansas City, Missouri, United States
Research Site
Albuquerque, New Mexico, United States
Research Site
Albany, New York, United States
Research Site
Long Island City, New York, United States
Research Site
The Bronx, New York, United States
Research Site
Asheville, North Carolina, United States
Research Site
Charlotte, North Carolina, United States
Research Site
Cincinnati, Ohio, United States
Research Site
Cincinnati, Ohio, United States
Research Site
Media, Pennsylvania, United States
Research Site
Columbia, South Carolina, United States
Research Site
Greenville, South Carolina, United States
Research Site
Chattanooga, Tennessee, United States
Research Site
Fort Worth, Texas, United States
Research Site
Houston, Texas, United States
Research Site
Irving, Texas, United States
Research Site
Lufkin, Texas, United States
Research Site
McKinney, Texas, United States
Research Site
Pasadena, Texas, United States
Research Site
San Antonio, Texas, United States
Research Site
San Antonio, Texas, United States
Research Site
Sherman, Texas, United States
Research Site
Stephenville, Texas, United States
Research Site
Sugar Land, Texas, United States
Research Site
Sugar Land, Texas, United States
Research Site
Arlington, Virginia, United States
Research Site
Richmond, Virginia, United States
Research Site
Salem, Virginia, United States
Research Site
Woodbridge, Virginia, United States
Research Site
CABA, Argentina
Research Site
Capital Federal, Argentina
Research Site
Ciudad de Buenos Aires, Argentina
Research Site
La Plata, Argentina
Research Site
Lanús Este, Argentina
Research Site
Mar del Plata, Argentina
Research Site
Rosario, Argentina
Research Site
Rosario, Argentina
Research Site
Rosario, Argentina
Research Site
San Nicolás, Argentina
Research Site
Santa Fe, Argentina
Research Site
Santa Fe, Argentina
Research Site
Feldkirch, Austria
Research Site
Innsbruck, Austria
Research Site
Linz, Austria
Research Site
Sankt Pölten, Austria
Research Site
Vienna, Austria
Research Site
Vienna, Austria
Research Site
Vienna, Austria
Research Site
Vienna, Austria
Research Site
Wels, Austria
Research Site
Wiener Neustadt, Austria
Research Site
Barretos, Brazil
Research Site
Belém, Brazil
Research Site
Belo Horizonte, Brazil
Research Site
Belo Horizonte, Brazil
Research Site
Campinas, Brazil
Research Site
Goiânia, Brazil
Research Site
Natal, Brazil
Research Site
Recife, Brazil
Research Site
São Caetano do Sul, Brazil
Research Site
São José do Rio Preto, Brazil
Research Site
São José dos Campos, Brazil
Research Site
São Paulo, Brazil
Research Site
São Paulo, Brazil
Research Site
São Paulo, Brazil
Research Site
São Paulo, Brazil
Research Site
Blagoevgrad, Bulgaria
Research Site
Nova Zagora, Bulgaria
Research Site
Pleven, Bulgaria
Research Site
Plovdiv, Bulgaria
Research Site
Sandanski, Bulgaria
Research Site
Sevlievo, Bulgaria
Research Site
Sofia, Bulgaria
Research Site
Sofia, Bulgaria
Research Site
Sofia, Bulgaria
Research Site
Stara Zagora, Bulgaria
Research Site
Varna, Bulgaria
Research Site
Calgary, Alberta, Canada
Research Site
Edmonton, Alberta, Canada
Research Site
Winnipeg, Manitoba, Canada
Research Site
Halifax, Nova Scotia, Canada
Research Site
Brampton, Ontario, Canada
Research Site
Greater Sudbury, Ontario, Canada
Research Site
London, Ontario, Canada
Research Site
Mississauga, Ontario, Canada
Research Site
Oakville, Ontario, Canada
Research Site
Toronto, Ontario, Canada
Research Site
Toronto, Ontario, Canada
Research Site
Waterloo, Ontario, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Québec, Quebec, Canada
Research Site
Baotou, China
Research Site
Beijing, China
Research Site
Beijing, China
Research Site
Beijing, China
Research Site
Beijing, China
Research Site
Changchun, China
Research Site
Changsha, China
Research Site
Changzhou, China
Research Site
Changzhou, China
Research Site
Chengdu, China
Research Site
Chengdu, China
Research Site
Chongqing, China
Research Site
Dongguan, China
Research Site
Dongyang, China
Research Site
Ganzhou, China
Research Site
Guangzhou, China
Research Site
Guangzhou, China
Research Site
Guiyang, China
Research Site
Hebei, China
Research Site
Hohhot, China
Research Site
Huaian, China
Research Site
Jinan, China
Research Site
Jining, China
Research Site
Jiujiang, China
Research Site
Linhai, China
Research Site
Nanchang, China
Research Site
Nanjing, China
Research Site
Nanjing, China
Research Site
Nanning, China
Research Site
Nanning, China
Research Site
Ningbo, China
Research Site
Ningbo, China
Research Site
Ningbo, China
Research Site
Ningbo, China
Research Site
Panjin, China
Research Site
Pingxiang, China
Research Site
Qingzhou, China
Research Site
Shanghai, China
Research Site
Shanghai, China
Research Site
Shanghai, China
Research Site
Shanghai, China
Research Site
Shanghai, China
Research Site
Shanghai, China
Research Site
Shanghai, China
Research Site
Shanghai, China
Research Site
Shantou, China
Research Site
Shenyang, China
Research Site
Shenzhen, China
Research Site
Shenzhen, China
Research Site
Suzhou, China
Research Site
Ürümqi, China
Research Site
Wuhan, China
Research Site
Wuhan, China
Research Site
Wuxi, China
Research Site
Xiamen, China
Research Site
Xiamen, China
Research Site
Xuzhou, China
Research Site
Yancheng, China
Research Site
Yangzhou, China
Research Site
Yangzhou, China
Research Site
Yantai, China
Research Site
Yibin, China
Research Site
Yinchuan, China
Research Site
Zhenjiang, China
Research Site
Zhuzhou, China
Research Site
Boulogne-sur-Mer, France
Research Site
Caen, France
Research Site
Cherbourg, France
Research Site
Colmar, France
Research Site
La Roche-sur-Yon, France
Research Site
Le Mans, France
Research Site
Marseille, France
Research Site
Nîmes, France
Research Site
Orléans, France
Research Site
Rouen, France
Research Site
Saint-Priez En Jarez, France
Research Site
Toulouse, France
Research Site
Tours, France
Research Site
Aachen, Germany
Research Site
Bad Nenndorf, Germany
Research Site
Berlin, Germany
Research Site
Berlin, Germany
Research Site
Berlin, Germany
Research Site
Bonn, Germany
Research Site
Brandenburg an der Havel, Germany
Research Site
Braunschweig, Germany
Research Site
Cloppenburg, Germany
Research Site
Essen, Germany
Research Site
Frankfurt am Main, Germany
Research Site
Fulda, Germany
Research Site
Gladbeck, Germany
Research Site
Goslar, Germany
Research Site
Hanover, Germany
Research Site
Heidelberg, Germany
Research Site
Leipzig, Germany
Research Site
Magdeburg, Germany
Research Site
München, Germany
Research Site
München, Germany
Research Site
Münster, Germany
Research Site
Nuremberg, Germany
Research Site
Nuremberg, Germany
Research Site
Obertshausen, Germany
Research Site
Riesa, Germany
Research Site
Rostock, Germany
Research Site
Rotenburg (Wümme), Germany
Research Site
Villingen-Schwenningen, Germany
Research Site
Würzburg, Germany
Research Site
Athens, Greece
Research Site
Athens, Greece
Research Site
Athens, Greece
Research Site
Heraklion, Greece
Research Site
Heraklion, Greece
Research Site
Ioannina, Greece
Research Site
Larissa, Greece
Research Site
Marousi, Greece
Research Site
Piraeus, Greece
Research Site
Rio, Greece
Research Site
Thessaloniki, Greece
Research Site
Aligarh, India
Research Site
Belagavi, India
Research Site
Bhubaneswar, India
Research Site
Calicut, India
Research Site
Coimbatore, India
Research Site
Dehli, India
Research Site
Dehradun, India
Research Site
Hyderabad, India
Research Site
Jaipur, India
Research Site
Jodhpur, India
Research Site
Kanpur, India
Research Site
Kochi, India
Research Site
Kolkata, India
Research Site
Mumbai, India
Research Site
Mumbai, India
Research Site
Mysore, India
Research Site
Nagpur, India
Research Site
New Delhi, India
Research Site
New Delhi, India
Research Site
New Delhi, India
Research Site
Pune, India
Research Site
Thiruvananthapuram, India
Research Site
Vijayawada, India
Research Site
Bari, Italy
Research Site
Bologna, Italy
Research Site
Cosenza, Italy
Research Site
Cremona, Italy
Research Site
Genoa, Italy
Research Site
Milan, Italy
Research Site
Modena, Italy
Research Site
Naples, Italy
Research Site
Palermo, Italy
Research Site
Pavia, Italy
Research Site
Ranica, Italy
Research Site
Verona, Italy
Research Site
Ageo, Japan
Research Site
Asahi-shi, Japan
Research Site
Chiba, Japan
Research Site
Fukaya, Japan
Research Site
Fukui-shi, Japan
Research Site
Izumisano, Japan
Research Site
Izunokuni-shi, Japan
Research Site
Kariya, Japan
Research Site
Kisarazu-shi, Japan
Research Site
Kita-ku, Japan
Research Site
Kitakyusyu-shi, Japan
Research Site
Kofu, Japan
Research Site
Koga-shi, Japan
Research Site
Komatsu-shi, Japan
Research Site
Koshigaya-shi, Japan
Research Site
Kumagaya-shi, Japan
Research Site
Kumamoto, Japan
Research Site
Kurashiki Shi, Japan
Research Site
Kuwana-shi, Japan
Research Site
Kyoto, Japan
Research Site
Kyoto, Japan
Research Site
Matsumoto-shi, Japan
Research Site
Minamiuonuma, Japan
Research Site
Minatoku, Japan
Research Site
Minokamo Shi, Japan
Research Site
Morioka, Japan
Research Site
Nagoya, Japan
Research Site
Nagoya, Japan
Research Site
Naka, Japan
Research Site
Nerima-ku, Japan
Research Site
Osaka, Japan
Research Site
Osaka, Japan
Research Site
Sendai, Japan
Research Site
Takatsuki-shi, Japan
Research Site
Toride-shi, Japan
Research Site
Tsu, Japan
Research Site
Urayasu, Japan
Research Site
Yokohama, Japan
Research Site
Cheras, Malaysia
Research Site
Ipoh, Malaysia
Research Site
Kajang, Malaysia
Research Site
Kota Kinabalu, Malaysia
Research Site
Kuala Lumpur, Malaysia
Research Site
Kuala Lumpur, Malaysia
Research Site
Kuantan, Malaysia
Research Site
Muar town, Malaysia
Research Site
Sarawak Miri, Malaysia
Research Site
Sungai Buloh, Malaysia
Research Site
Benito Juárez, Mexico
Research Site
Culiacán, Mexico
Research Site
Culiacán, Mexico
Research Site
Durango, Mexico
Research Site
Ecatepec de Morelos, Mexico
Research Site
Estado de México, Mexico
Research Site
Mexico City, Mexico
Research Site
México, Mexico
Research Site
Tuxpan, Mexico
Research Site
Veracruz, Mexico
Research Site
Villahermosa, Mexico
Research Site
Xalapa, Mexico
Research Site
Callao, Peru
Research Site
Chorrillos, Peru
Research Site
Cusco, Peru
Research Site
Lima, Peru
Research Site
Lima, Peru
Research Site
Lima, Peru
Research Site
Lima, Peru
Research Site
Lima, Peru
Research Site
Lima, Peru
Research Site
Lima, Peru
Research Site
Piura, Peru
Research Site
Trujillo, Peru
Research Site
Dasmariñas, Philippines
Research Site
Davao DEL SUR, Philippines
Research Site
Iloilo City, Philippines
Research Site
Las Piñas, Philippines
Research Site
Manila, Philippines
Research Site
Quezon City, Philippines
Research Site
Quezon City, Philippines
Research Site
West San Juan City, Philippines
Research Site
Olsztyn, Poland
Research Site
Warsaw, Poland
Research Site
Warsaw, Poland
Research Site
Węgrów, Poland
Research Site
Wroclaw, Poland
Research Site
Żywiec, Poland
Research Site
Brasov, Romania
Research Site
Bucharest, Romania
Research Site
Bucharest, Romania
Research Site
Bucharest, Romania
Research Site
Craiova, Romania
Research Site
Galati, Romania
Research Site
Oradea, Romania
Research Site
Timișoara, Romania
Research Site
Anyang, South Korea
Research Site
Cheonan-si, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Wŏnju, South Korea
Research Site
Yangsan, South Korea
Research Site
Badajoz, Spain
Research Site
Barcelona, Spain
Research Site
Barcelona, Spain
Research Site
Barcelona, Spain
Research Site
Córdoba, Spain
Research Site
Girona, Spain
Research Site
Madrid, Spain
Research Site
Madrid, Spain
Research Site
Majadahonda, Spain
Research Site
Talavera de la Reina, Spain
Research Site
Valencia, Spain
Research Site
Valencia, Spain
Research Site
Changhua, Taiwan
Research Site
Hualien City, Taiwan
Research Site
Kaohsiung City, Taiwan
Research Site
Kaohsiung City, Taiwan
Research Site
New Taipei City, Taiwan
Research Site
Taichung, Taiwan
Research Site
Taichung, Taiwan
Research Site
Taichung, Taiwan
Research Site
Taichung, Taiwan
Research Site
Tainan, Taiwan
Research Site
Tainan, Taiwan
Research Site
Taipei, Taiwan
Research Site
Taipei, Taiwan
Research Site
Taipei, Taiwan
Research Site
Taoyuan, Taiwan
Research Site
Zhubei, Taiwan
Research Site
Bangkok, Thailand
Research Site
Bangkok, Thailand
Research Site
Bangkok, Thailand
Research Site
Bangkok, Thailand
Research Site
Banphaeo, Thailand
Research Site
Changwat Sara Buri, Thailand
Research Site
Chiang Mai, Thailand
Research Site
Hat Yai, Thailand
Research Site
Naimuang, Thailand
Research Site
Phitsanulok, Thailand
Research Site
Ubonratchathani, Thailand
Research Site
Adapazarı, Turkey (Türkiye)
Research Site
Ankara, Turkey (Türkiye)
Research Site
Antalya, Turkey (Türkiye)
Research Site
Dinar, Turkey (Türkiye)
Research Site
İzmit, Turkey (Türkiye)
Research Site
Kahramanmaraş, Turkey (Türkiye)
Research Site
Kayseri, Turkey (Türkiye)
Research Site
Kazımkarabekir, Turkey (Türkiye)
Research Site
Malatya, Turkey (Türkiye)
Research Site
Samsun, Turkey (Türkiye)
Research Site
Ivano-Frankivsk, Ukraine
Research Site
Kyiv, Ukraine
Research Site
Kyiv, Ukraine
Research Site
Kyiv, Ukraine
Research Site
Kyiv, Ukraine
Research Site
Kyiv, Ukraine
Research Site
Kyiv, Ukraine
Research Site
Kyiv, Ukraine
Research Site
Kyiv, Ukraine
Research Site
Lviv, Ukraine
Research Site
Vinnytsia, Ukraine
Research Site
Vinnytsia, Ukraine
Research Site
Vinnytsia, Ukraine
Research Site
Aberdeen, United Kingdom
Research Site
Bristol, United Kingdom
Research Site
Cardiff, United Kingdom
Research Site
Dundee, United Kingdom
Research Site
Glasgow, United Kingdom
Research Site
London, United Kingdom
Research Site
London, United Kingdom
Research Site
London, United Kingdom
Research Site
London, United Kingdom
Research Site
Swansea, United Kingdom
Research Site
Can Tho, Vietnam
Research Site
Da Nang, Vietnam
Research Site
Da Nang, Vietnam
Research Site
Hanoi, Vietnam
Research Site
Hanoi, Vietnam
Research Site
Hà Nội, Vietnam
Research Site
Ho Chi Minh City, Vietnam
Research Site
Ho Chi Minh City, Vietnam
Research Site
Hochiminh City, Vietnam
Research Site
Hochiminh, Vietnam
Research Site
Huế, Vietnam