Clinical Research Directory
Browse clinical research sites, groups, and studies.
Letrozole Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy
Sponsor: Kafrelsheikh University
Summary
The aim of work is to study the effectiveness of letrozole in treatment of early undisturbed ectopic pregnancy in comparison with Methotrexate.
Key Details
Gender
FEMALE
Age Range
20 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2026-06
Completion Date
2027-07
Last Updated
2026-06-03
Healthy Volunteers
No
Conditions
Interventions
Methotrexate (drug)
Methotrexate is a folic acid antagonist that inhibits the enzyme dihydrofolate reductase, which converts folic acid to tetrahydrofolate, a cofactor needed in DNA and RNA synthesis
Letrozole 2.5Mg Tab
Aromatase inhibitors has been shown toSuccessfully block estrogen production In the absence of estrogen priming, progesterone may not exert its physiological functions due to a negative effect on progesterone receptors. It was hypothesized that by inhibiting the estrogen synthetase (the aromatase enzyme), the progesterone would not exert its physiological function in maintaining pregnancy, including ectopic pregnancy
Locations (1)
Kafr El-Sheikh University
Kafr ash Shaykh, Kafr el-Sheikh Governorate, Egypt