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To Evaluate Efficacy of Monotherapy of Oxcarbazepine Versus Combination of Gabapentin With Oxcarbazepine in the Management of Trigeminal Neuralgia
Sponsor: Rehman Medical Institute - RMI
Summary
ABSTRACT: Objective: This study evaluates the effectiveness of oxcarbazepine monotherapy with the combination of gabapentin and oxcarbazepine in managing trigeminal neuralgia(TN). Methods: A prospective observational study was conducted at Rehman College of Dentistry for the duration of one year, i.e., from 1st May 2023 till May 2024. A total of 44 patients, fulfilling inclusion criteria, were included.Half were given monotherapy with oxcarbazepine (300 mg twice daily) and half were given combination therapy with gabapentin (100 mg daily) plus oxcarbazepine. Pain was evaluated utilizing the Visual Analogue Scale (VAS) at baseline, 2 weeks, and 2 months. SPSS software version 26 was used for statistical analysis. KEYWORDS: Combination Therapy, Gabapentin, Monotherapy, Oxcarbazepine, Trigeminal Neuralgia, Visual Analogue Scale.
Official title: To Evaluate Efficacy of Monotherapy of Oxcarbazepine Versus Combination of Gabapentin With Oxcarbazepine in the Management of Trigeminal Neuralgia.
Key Details
Gender
All
Age Range
20 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
44
Start Date
2023-05-01
Completion Date
2024-05-01
Last Updated
2026-06-04
Healthy Volunteers
No
Interventions
oxcarbamezapine(300 mg twice daily)
monotherapy with oxcarbamezapine(300 mg twice daily)
combination therapy(oxcarbamezapine 300 mg twice daily and gabapentine)
combination therapy of oxcarbamezapine with gabapentine was given
Locations (1)
Rehman College of Dentistry
Peshawar, Khyber Pakhtunkhwa, Pakistan