Clinical Research Directory

Inclusion Criteria: 1. Male or female subjects, Age ≥ 18 years at the time of signing informed consent; 2. Clinically diagnosed with chronic kidney disease at screening; 3. CKD treatment plan consistent with current clinical guidelines or local standard of care; 4. eGFR ≥ 20 mL/min/1.73 m² and UACR meeting protocol-specified criteria at screening and prior to randomization; 5. Able and willing to provide a written informed consent; Exclusion Criteria: 1. Uncontrolled severe hypertension prior to randomization (systolic blood pressure ≥ 180 mmHg and/or diastolic blood pressure ≥ 110 mmHg); or systolic blood pressure \< 90 mmHg. 2. Body mass index (BMI) \< 20 kg/m² at screening and prior to randomization. 3. Prior history of renal transplantation, or planned renal transplantation during the trial; 4. History or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN2). 5. History of acute or chronic pancreatitis, pancreatic injury, acute cholecystitis, or symptomatic/treatable gallbladder disease (excluding cholecystectomy recipients); 6. Occurrence of acute kidney injury or receipt of dialysis treatment within 3 months prior to screening or randomization; 7. Presence of severe gastrointestinal diseases within 3 months prior to screening or randomization, or a history of major gastrointestinal surgery affecting gastric accommodation or gastric emptying; 8. Any condition deemed inappropriate for participation in this clinical trial by the investigator.