Clinical Research Directory

Inclusion Criteria: * Male or female * 18 and 80 years of age. * Patients who manifest dystonia - sustained involuntary movement of the head, neck, trunk or limbs. * The dystonia may be spontaneous or genetic, specifically DYT1 or DYT6 and then only those patients who are demonstrating dystonia. The patient/subject will have a normal neurological exam except for dystonia. Exclusion Criteria: * Heredodegenrative dystonia of the type DYT8,9 or 10. * Past history of head trauma, stroke, epilepsy, demyelinating disease * Hypertension in excess of 160mmHg systolic and 90mmHg diastolic * Congestive heart failure * Diabetes * Past psychiatric conditions: e.g., depression * Systemic metabolic disease: e.g., Wilson's disease, progressive neurodegenerative disease (like supranuclear palsy or corticobasal ganglionic degeneration) * Magnetizable incorporated metal parts - like pacemakers * History or diagnosis of Parkinson's disease * Presence of myoclonus * No previous surgery for dystonia * Long term exposure to benzodiazepines, neuroleptics or anticonvulsants * No botulinum toxin within 12 weeks of baseline assessment and fMRI. * Moderate to severe cognitive impairment (judged by a minimental status of \<24.)