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Increasing Uptake of Cascade Testing in Families With Familial Cancer Syndromes: A Randomized Controlled Trial of a Registry-aided Model.
Sponsor: National Cancer Centre, Singapore
Summary
The purpose of this study is to compare the uptake rates of a patient-initiated model of cascade testing with a registry-aided model amongst relatives of patients identified to have a particular cancer predisposition gene. Cascade testing allows the benefits of genetic testing to spread beyond the patient and enables other family members to make an informed choice on genetic testing. The researcher team hopes to study the rates of cascade testing using the two models, while concurrently comparing the adherence of identified carriers to risk management recommendations, including surveillance imaging and/or prophylactic surgeries. The team also aims to understand the willingness, acceptability and barriers of a registry-aided model.
Key Details
Gender
All
Age Range
21 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
545
Start Date
2021-12-10
Completion Date
2026-02-06
Last Updated
2026-06-04
Healthy Volunteers
Yes
Conditions
Interventions
Proband-dependent approach
Probands assigned to the control arm will be offered family letters to distribute to their at-risk relatives (ARRs). These family letters encourage relatives to see a general practitioner for a referral to genetic counselling and cascade testing.
Combination of the proband-dependent approach with additional registry-aided testing reminders
Like the control arm, probands will be given the same family letters to distribute to their ARRs. In addition, a genetics coordinator will contact their first-degree relatives (FDRs) by phone/ email to inform them about genetic testing and advise them to obtain a referral from a general practitioner. The coordinator will remind relatives of their eligibility for genetic testing and assist them with queries at 1, 3, and 6 months after initial contact. Upon visiting for pre-test genetic counselling, FDRs will be further invited to provide contact details of other untested.
Locations (1)
National Cancer Centre, Singapore
Singapore, Singapore