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Prenatal Androgen and Skills
Sponsor: Nigde Omer Halisdemir University
Summary
Due to the difficulties and risks of directly measuring prenatal hormone levels, biomarkers that indirectly reflect this exposure are used in research. In this context, the ratio of second to fourth finger length (2D:4D) is widely preferred because it is an easily applicable and non-invasive measurement. Evidence shows that 2D:4D stabilizes from the second trimester of pregnancy onward and exhibits strong sex differences across populations. The 2D:4D ratio is generally lower in men than in women. 2D is more strongly influenced by prenatal estrogen, while 4D is more strongly influenced by prenatal testosterone; this occurs during the first trimester of intrauterine fetal development. To our knowledge, studies examining the relationship between the 2D:4D ratio, an indirect indicator of prenatal androgen exposure, and dexterity and tactile discrimination are limited. Accordingly, the planned study aims to evaluate the relationship between the 2D:4D ratio and fine motor skills and tactile discrimination in healthy young adults.
Official title: Prenatal Androgen and Fine Motor Skills and Tactile Discrimination
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
OBSERVATIONAL
Enrollment
94
Start Date
2026-10-01
Completion Date
2027-07-01
Last Updated
2026-09-23
Healthy Volunteers
Yes
Conditions
Interventions
Digit Ratio
The second (2D) and fourth (4D) finger lengths of the participants will be measured separately in both hands by a physiotherapist with over thirteen years of clinical experience.
Fine motor skills
Hand dexterity will be assessed using the Purdue Pegboard Test. The test will be administered according to standard procedure with participants seated at a table. Participants will be asked to place the pegs into the corresponding holes as quickly and accurately as possible within a specified time (30 seconds).
Tactile Discrimination
To perform the 2-point discrimination tests, the Baseline® two-point discriminator will be used. Measurements will be applied to the distal phalangeal pulp of the index finger on both hands while participants are seated in a comfortable position with their eyes closed.
Locations (1)
Nigde Omer Halisdemir University
Niğde, Merkez, Turkey (Türkiye)