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RECRUITING
NCT07628049
PHASE1/PHASE2

A Study of Investigational RSV/hMPV Combination and Investigational hMPV Vaccines in Younger and Older Adults

Sponsor: GlaxoSmithKline

View on ClinicalTrials.gov

Summary

The aim of this study is to evaluate the safety, reactogenicity, and immune response of the different formulations of the investigational RSV/hMPV combination vaccine and investigational hMPV vaccine in younger and older adults.

Official title: A Phase 1/2, Randomized, Controlled, Observer-blind, Multicentre Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of GSK Biologicals' Investigational Respiratory Syncytial Virus (RSV)/Human Metapneumovirus (hMPV) Combination and Investigational hMPV Vaccines When Administered Intramuscularly According to a Single Dose Schedule in Younger Adults ≥18 to ≤49 Years and Older Adults Aged ≥60 to ≤80 Years

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

1808

Start Date

2026-06-05

Completion Date

2029-04-05

Last Updated

2026-07-08

Healthy Volunteers

Yes

Interventions

BIOLOGICAL

RSV/hMPV_V low dose vaccine

RSV/hMPV\_V low dose vaccine administered intramuscularly.

BIOLOGICAL

RSV/hMPV_V medium dose vaccine

RSV/hMPV\_V medium dose vaccine administered intramuscularly.

BIOLOGICAL

RSV/hMPV_V high dose vaccine

RSV/hMPV\_V high dose vaccine administered intramuscularly.

BIOLOGICAL

RSV/hMPV_W low dose vaccine

RSV/hMPV\_W low dose vaccine administered intramuscularly.

BIOLOGICAL

RSV/hMPV_W medium dose vaccine

RSV/hMPV\_W medium dose vaccine administered intramuscularly.

BIOLOGICAL

RSV/hMPV_W high dose vaccine

RSV/hMPV\_W high dose vaccine administered intramuscularly.

BIOLOGICAL

RSV/hMPV_X low dose vaccine

RSV/hMPV\_X low dose vaccine administered intramuscularly.

BIOLOGICAL

RSV/hMPV_X medium dose vaccine

RSV/hMPV\_X medium dose vaccine administered intramuscularly.

BIOLOGICAL

RSV/hMPV_X high dose vaccine

RSV/hMPV\_X high dose vaccine administered intramuscularly.

BIOLOGICAL

hMPV_Y low dose vaccine

hMPV\_Y low dose vaccine administered intramuscularly.

BIOLOGICAL

hMPV_Y medium dose vaccine

hMPV\_Y medium dose vaccine administered intramuscularly.

BIOLOGICAL

hMPV_Y high dose vaccine

hMPV\_Y high dose vaccine administered intramuscularly.

BIOLOGICAL

hMPV_Z low dose vaccine

hMPV\_Z low dose vaccine administered intramuscularly.

BIOLOGICAL

hMPV_Z medium dose vaccine

hMPV\_Z medium dose vaccine administered intramuscularly.

BIOLOGICAL

hMPV_Z high dose vaccine

hMPV\_Z high dose vaccine administered intramuscularly.

BIOLOGICAL

Control vaccine

Control vaccine administered intramuscularly.

COMBINATION_PRODUCT

Placebo

Placebo administered intramuscularly.

Locations (4)

GSK Investigational Site

Lenexa, Kansas, United States

GSK Investigational Site

Seattle, Washington, United States

GSK Investigational Site

Botany, New South Wales, Australia

GSK Investigational Site

Camberwell, Victoria, Australia