Clinical Research Directory

All of the following criteria must be met: Inclusion Criteria: * Age 18 years or older. * Refractory obesity, defined as BMI \>= 35 kg/m2 despite adherence to and tolerance of treatment with highest available dose of chronic weight management therapy. * Two or more serious or life-threatening obesity-related complications for which the patient is currently receiving standard of care * Unable to participate in an ongoing clinical trial of retatrutide or a similar/comparable investigational medicine (due to trial eligibility criteria or lack of a reasonably accessible enrolling site). * All standard treatment options including bariatric surgery discussed with the patient through shared decision-making. Exclusion Criteria: * Medical contraindication to retatrutide therapy