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NOT YET RECRUITING
NCT07631299
EARLY_PHASE1

Nebulized AER101 in Pre-op NSCLC

Sponsor: University of Oklahoma

View on ClinicalTrials.gov

Summary

The primary objective of this pilot study is to determine if AER101 can decrease glycolysis in non-small cell lung cancer (NSCLC). Glycolysis is the process cells use to break down sugar (glucose) into a smaller substance in the fluid part inside the cell. Many lung cancers begin in bronchi, bronchioles and alveoli cells surrounding the airways, which enables nebulization to deposit AER101 on lung tumors. Participants in the study will self-administer AER101 via a hand-held personal nebulizer three times per day (dosing at least 4 hours apart) for 14 days prior to undergoing surgery for lung cancer.

Official title: Nebulized AER101 to Inhibit Glycolysis for Pre-Operative Non-small Cell Lung Cancer (NSCLC)

Key Details

Gender

All

Age Range

18 Years - 100 Years

Study Type

INTERVENTIONAL

Enrollment

5

Start Date

2026-06

Completion Date

2027-06

Last Updated

2026-06-08

Healthy Volunteers

No

Interventions

DRUG

AER101

Nebulization of AER101

Locations (2)

OU Medical Center Hospital

Oklahoma City, Oklahoma, United States

Stephenson Cancer Center

Oklahoma City, Oklahoma, United States