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Pseudoallergen-Free and Low-Histamine Diet in Adolescents With Chronic Spontaneous Urticaria
Sponsor: Istanbul University
Summary
The goal of this clinical trial is to learn whether a histamine- and pseudoallergen-restricted diet can help reduce symptoms in people with chronic urticaria. It will also learn whether this diet changes the need for urticaria medication. The main questions it aims to answer are: Does the diet lower urticaria activity, including hives and itching? Does the diet improve disease control and quality of life? Does the diet change the need for urticaria medication? Which clinical or laboratory factors may affect response to the diet? There is no comparison group. Researchers will compare participants' symptoms before and after the diet. Participants will: Follow a structured histamine- and pseudoallergen-restricted diet Continue their usual urticaria treatment as recommended by their doctor Record or report their urticaria symptoms during follow-up Visit the clinic for assessment of symptoms, disease control, quality of life, medication use, and laboratory findings.
Official title: Clinical Response to a Histamine- and Pseudoallergen-Restricted Diet in Patients With Chronic Urticaria
Key Details
Gender
All
Age Range
1 Year - 18 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2025-11-24
Completion Date
2027-01
Last Updated
2026-06-08
Healthy Volunteers
No
Conditions
Interventions
Intervention Name: Low-histamine and pseudoallergen-free diet
Participants assigned to the intervention group will receive a structured low-histamine and pseudoallergen-free diet for 4 weeks in addition to standard guideline-based clinical care. The diet will restrict histamine-rich foods, foods considered to promote histamine release, and foods containing common pseudoallergen sources such as selected additives, preservatives, colorants, and naturally occurring pseudoallergen-rich foods. Antihistamine treatment will be permitted according to clinical need.
General healthy eating advice
Participants assigned to the control group will receive standard guideline-based clinical care together with general age-appropriate healthy eating advice. No specific restriction of histamine-rich foods, histamine-releasing foods, or pseudoallergen-containing foods will be recommended during the primary 4-week comparison period. Antihistamine treatment will be permitted according to clinical need.
Locations (1)
Istanbul University, Istanbul Faculty of Medicine, Department of Pediatric Allergy and Immunology
Istanbul, Fatih, Turkey (Türkiye)