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RECRUITING
NCT07632456
NA

Exploring the Role of taVNS in Nausea Management

Sponsor: Daniel Keszthelyi

View on ClinicalTrials.gov

Summary

This single-center randomized controlled trial aims to investigate the efficacy of transcutaneous auricular vagus nerve stimulation in alleviating nausea in healthy adults. The primary aim of this study is to assess the efficacy of taVNS in reducing nausea in healthy adults subjected to nausea induction through intragastric lipid infusion, compared to sham stimulation, as measured by 0-100 Visual Analogue Scale (VAS) scores. The secondary objectives include evaluating the potential of taVNS to alleviate other gastrointestinal symptoms, such as abdominal pain, bloating, and fullness, as well as exploring its effects on the desire to eat, all measured using 0-100 VAS scores. Additionally, changes in autonomic parameters, plasma levels of ghrelin and motilin, and salivary cortisol will be evaluated. The relationship between the nausea response and affective symptoms, as well as personality traits, will also be explored. Participants will be randomly assigned to either the taVNS or the sham stimulation group, with the intervention administered for 30 minutes immediately following nausea induction through intragastric lipid infusion.

Official title: Exploring the Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation in Alleviating Nausea in Healthy Adults: a Double-blind Randomized Controlled Trial

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

35

Start Date

2025-12-08

Completion Date

2026-09

Last Updated

2026-06-08

Healthy Volunteers

Yes

Interventions

DEVICE

Vagal Nerve Stimulation

Transcutaneous Auricular Vagal Nerve Stimulation

DEVICE

Sham stimulation

Sham stimulation with a non-conducting electrode

Locations (1)

Maastricht University

Maastricht, Limburg, Netherlands