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Diagnostic Value of the Liver Inflammation Index for MASH in Patients With T2DM and MAFLD
Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Summary
This observational study aims to evaluate a new diagnostic tool, the Liver Inflammation Index, in detecting Metabolic Dysfunction-Associated Steatohepatitis (MASH) among adults who have both Type 2 Diabetes Mellitus (T2DM) and Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD).
Official title: A Multicenter Cross-Sectional Study Evaluating the Diagnostic Accuracy of the Liver Inflammation Index for Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Patients With Concurrent Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Fatty Liver Disease
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
10000
Start Date
2026-05-15
Completion Date
2027-12-31
Last Updated
2026-06-08
Healthy Volunteers
No
Conditions
Interventions
iLivTouch (Vibration-controlled transient elastography)
A non-invasive diagnostic assessment performed using the iLivTouch device. This device simultaneously generates three key metrics: the Liver Inflammation Index (the primary target evaluated for its accuracy in detecting MASH), the Ultrasound Attenuation Parameter (UAP) for hepatic steatosis grading, and the Liver Stiffness Measurement (LSM) for fibrosis staging.
Locations (22)
Department of Endocrinology, the First Affiliated Hospital of Bengbu Medical University
Bengbu, Anhui, China
Department of Endocrinology, the Second Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China
Department of Endocrinology, the Second Affiliated Hospital of Wannan Medical University
Wuhu, Anhui, China
Department of Endocrinology, Zhujiang Hospital, Southern Medical University
Guangzhou, Guangdong, China
Department of Obesity and Metabolic Diseases, Panyu Hospital of Traditional Chinese Medicine
Guangzhou, Guangdong, China
Department of Endocrinology, the Eighth Affiliated Hospital, Sun Yat-sen University
Shenzhen, Guangdong, China
Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi, China
Department of Endocrinology, the Affiliated Hospital of Zunyi Medical University
Zunyi, Guizhou, China
Department of Endocrinology, Hainan General Hospital
Haikou, Hainan, China
Department of Endocrinology, the First Affiliated Hospital of Henan University of CM
Zhengzhou, Hennan, China
Department of Endocrinology, Renmin Hospital of Wuhan University
Wuhan, Hubei, China
Department of Endocrinology, the First Affiliated Hospital of University of South China
Hengyang, Hunan, China
Department of Endocrinology, Endocrine and Metabolic Disease Medical Center,Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
Nanjing, Jiangsu, China
Department of Endocrinology, the First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China
Department of Endocrinology, Xuzhou Central Hospital
Xuzhou, Jiangsu, China
Department of Endocrinology, the Affiliated Hospital of Qingdao University
Qingdao, Shandong, China
Department of Metabolic Diseases and Weight Management, Weifang People's Hospital
Weifang, Shandong, China
Department of Endocrinology, ZhongShan Hospital, Fudan University
Shanghai, Shanghai Municipality, China
Department of Endocrinology and Metabolism, Xijing Hospital, Air Force Medical University
Xi’an, Shanxi, China
Department of Endocrinology, the Third People's Hospital of Yunnan Province
Kunming, Yunnan, China
Department of Endocrinology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China