Clinical Research Directory

Inclusion Criteria: * \- Participant must be 18 years of age or older, at the time of signing the informed consent. * \- Confirmed diagnosis of CRSwNP for at least 12 months prior to routine care visit 1. * \- Stable standard of care (SoC) treatment with Intranasal corticosteroids (INCS) for CRSwNP for at least 30 days prior to routine care visit 1. * \- Physician decision that participant is eligible for treatment with Tezepelumab according to locally approved CRSwNP label. * Participants must be able and willing to read and comprehend written instructions, to collect Patient-reported outcome (PROs) and medication intake via app or alternative mode (paper) and to sign the informed consent document. Use of the mobile app is optional; participants without smartphones will not be excluded. Mode of data capture will be recorded and adjusted for in analyses where relevant. * \- Participants who will be enrolled after index date need to have at least one measurement for SNOT-22 prior (within a maximum of 4 weeks) to index date. * \- - Exclusion Criteria: * \- Participants who participate in an observational study that might influence the assessment of the current study (participants can be part of the German National Registry for Chronic rhinosinusitis (GENRE-CRS)); or participate in an interventional clinical trial in the last 3 months. * \- Concurrent biologic therapy for CRSwNP or Asthma except where the last dose was administered ≥ 30 days. Stable allergen immunotherapy (defined as a stable dose and regimen at the time of enrolment) is allowed. * \- Endoscopic NP surgery within 6 months prior to index date. * \- Condition (acute or chronic) that, in the investigator's opinion, would limit the participant's ability to complete questionnaires or participate in this study. * \- History of documented anaphylactic reactions/hypersensitivity/serious allergic reactions (immune complex disease) following any biologic therapy. * \- Known hypersensitivity to Tezepelumab or any of its excipients. * \- Pregnancy, planned pregnancy or lactation period. * \- -