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Phenotype Guided Vasoactive Medication During Kidney Transplantation
Sponsor: Jennifer Cutler
Summary
The goal of this clinical trial is to learn if vasopressin improves the body's response to intravenous fluids during kidney transplantation in patients who have relaxed blood vessels. Researchers will compare the results of vasopressin to those who received calcium chloride.
Official title: Intraoperative Circulation Phenotyping to Guide Vasoactive Medication in Kidney Transplant Recipients
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
255
Start Date
2026-06-01
Completion Date
2027-12-01
Last Updated
2026-06-08
Healthy Volunteers
No
Conditions
Interventions
Phenotype-Guided Vasoactive Management
Recipients undergo intraoperative circulation phenotyping using pulse contour monitoring and flow-pressure coupling testing. Vasoactive support is assigned according to phenotype: vasopressin infusion for Hyperdynamic physiology, norepinephrine infusion for Mixed Physiology, calcium chloride and/or low-dose dopamine for Poor Contractility, and fluid-guided support for Normal physiology.
Locations (1)
Cedars Sinai Medical Center
Los Angeles, California, United States