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Protective Effect of Exercise on Acute High-fat Overfeeding
Sponsor: George Washington University
Summary
Metabolic flexibility is the ability to switch rapidly from one substrate (i.e. fuel source) to another (e.g. fats to carbohydrates) in response to ingested foods. Worse metabolic flexibility is linked to worse metabolic outcomes, but exercise is thought to be protective against nutrient excess. We will conduct a standard oral glucose tolerance test (OGTT) to assess insulin resistance and metabolic flexibility. Participants will be randomized to a 24-hour hypercaloric, high-fat diet (HFD) with and without an exercise bout. During the hypercaloric HFD, participants will eat extra calories with more calories from fat than normal, which is expected to increase insulin resistance. After each arm of the high-fat diet, we will repeat the OGTT. During each OGTT, expired gases will be analyzed noninvasively to determine metablic flexibility. Insulin resistance will be determined with blood drawn during each OGTT. By comparing metabolic flexiblity and insulin resistance before and after the normal diet and after the high-fat diet intervention, a better understanding of how insulin resistance affects metabolism and how exercise can be protective will be developed.
Key Details
Gender
All
Age Range
20 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2025-02-10
Completion Date
2026-04-09
Last Updated
2026-06-08
Healthy Volunteers
Yes
Conditions
Interventions
High Fat Overfeeding
Caloric intake 180% of daily caloric need with 65% from fat
High Fat Overfeeding + Exercise
Caloric intake 180% of daily caloric need with 65% from fat with acute moderate exercise (energy expenditure \~25% of daily caloric need).
Locations (1)
Milken Institute School of Public Health
Washington D.C., District of Columbia, United States