Clinical Research Directory

Inclusion Criteria: 1. Age≥18 years, any gender; 2. Patients with VBD confirmed by DSA/CTA/MRA; 3. No history of VBD rupture and no surgical treatment for VBD; 4. mRS\<4; 5. Positive plasma SGK1; 6. No history of posterior circulation stroke, and no symptoms or signs related to VBD; 7. No need for subsequent use of antiplatelet or statin drugs; 8. Capable of signing an informed consent form with the accompaniment and understanding of a guardian. Exclusion Criteria: 1. History of malignant tumors, systemic lupus erythematosus, or gout; 2. Pregnancy or lactation; 3. Amiloride or sulfonamide allergy; 4. Hydrocephalus requiring urgent surgical intervention or respiratory failure requiring life support treatment; 5. Abnormal hepatic and/or renal function (serum transaminase \> 40 U/L; serum creatinine \> 110 μmol/L); and/or abnormal white blood cells/platelets (white blood cells count \< 3.5 × 10⁹/L or \> 9.5 × 10⁹/L; platelets count \< 100 × 10⁹/L or \> 300 × 10⁹/L); hyperkalemia, hypokalemia, hyponatremia, or hypercalcemia; 6. Acute cerebral infarction within the last month or definite high signal on DWI indicating acute or subacute cerebral infarction; 7. Acute stage of intracranial hemorrhage as indicated by CT; 8. History of VBD rupture or surgery; 9. Presence of acute active infection (such as severe bacterial, viral or fungal infection); 10. Uncontrolled diabetes (HbA1c≥7%); 11. Need for subsequent use of antiplatelet or statin drugs; 12. Systolic blood pressure\< 90 mmHg or/and diastolic blood pressure\< 60 mmHg; 13. Currently participating in other clinical studies; 14. Presence of contraindications for MRI examination; 15. Other situations not suitable for inclusion.