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Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment
Sponsor: Montefiore Medical Center
Summary
The IMPACT study is a randomized, double-blind clinical trial evaluating two commonly used intravenous medications - metoclopramide and acetaminophen - for treating acute post-concussion symptoms in emergency department patients after mild head injury. The study aims to determine which treatment more effectively improves symptoms such as headache, dizziness, nausea, concentration difficulties, and emotional changes within the first week after injury. Participants will be enrolled across two Montefiore emergency departments and followed using a validated post-concussion symptom questionnaire. Findings from this study may help improve evidence-based treatment strategies for patients experiencing concussion-related symptoms after head trauma.
Official title: A Randomized Study of Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2026-08-01
Completion Date
2028-08-04
Last Updated
2026-06-10
Healthy Volunteers
No
Interventions
Metoclopramide 10mg
Intravenous drip
Acetaminophen
Intravenous drip over 15 minutes
Locations (1)
Montefiore Medical Center
New York, New York, United States