Clinical Research Directory

Inclusion Criteria: 1\. Patients aged 40 to 100 years who are scheduled to undergo total knee arthroplasty. Exclusion Criteria: 1. Participants who used antiretroviral agents within 4 weeks before the first administration of Livact. 2. Participants who used medications associated with fatty liver within 4 weeks before the first administration of Livact, including thiazolidinediones, sodium glucose cotransporter 2 inhibitors, amiodarone, methotrexate, tamoxifen, valproate, or corticosteroids. 3. Participants who used branched chain amino acid products or multinutritional supplements within 4 weeks before the first administration of Livact. 4. Participants who used pain medications other than those prescribed for total knee arthroplasty treatment within 2 weeks before the first administration of Livact. 5. Participants with markedly decreased hepatic protein synthetic function. 6. Participants with congenital branched chain amino acid metabolism disorders. 7. Participants with hereditary galactose intolerance, Lapp lactase deficiency, or glucose galactose malabsorption. 8. Participants with a history of high tibial osteotomy. 9. Participants with neurologic diseases such as stroke or Parkinson disease. 10. Participants with gait disturbance due to causes other than arthritis. 11. Participants taking medication for spinal stenosis. 12. Participants with a history of hypersensitivity to the investigational product or its components. 13. Pregnant or breastfeeding participants. 14. Participants planning pregnancy during the trial or who have the possibility of pregnancy but do not agree to use appropriate contraception during the trial. 15. Participants judged by the investigator to be inappropriate for participation in the clinical trial.