Clinical Research Directory

Inclusion Criteria: * Men and women ≥ 60 years old * Average office systolic BP ≥130 mmHg5 * Self-reported skipping breakfast for at least 3 days in the past 7 days * Identified as having a morning or evening chronotype according to the Morningness-Eveningness Questionnaire68 * Stable health history over the past 2 months * Stable medication history over the past 2 months, as recommended by the primary provider * Willing and able to provide informed consent. Exclusion Criteria: * Fasting \>13 hours per day * Actively trying to lose weight by participating in formal weight loss program or significantly restricting calorie intake * Resting heart rate of \>120 beats/minute, systolic BP \>180 and/or diastolic BP \>100 mmHg * Have lost ≥ 10 pounds in last 3 months * Self-reported exercise over 90 min/week * Unable to wake up at a regular time between 6-9 am * Perform overnight shift work more than 1day/week on average * Have been diagnosed with diabetes * On insulin or diabetes medication * Unstable angina, heart attack or stroke in the past 3 months * Continuous use of supplemental oxygen to manage a chronic pulmonary condition or heart failure * Pregnant or breastfeeding * Rheumatoid arthritis, Parkinson's disease or currently on dialysis * Current diagnosis of a major psychiatric condition that would impair study participation * Severe gastrointestinal disease, major gastrointestinal surgery, or active gallstone disease * Active treatment for cancer in the past year * Taking medications that preclude fasting for 16 hours (e.g. must be taken with food at least 12 hours apart) * Diagnosed cognitive impairment * Unable to fast for 16 hours. * Any condition that in the opinion of the investigator would impair ability to participate in the trial