Inclusion Criteria (Healthy Volunteers):
* Age 7 years or older
* Willing and able to complete study procedures
Exclusion Criteria (Healthy Volunteers):
* Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
* Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)
* Received ferumoxytol injection within previous one year (clinical or research)
* Patients requiring intravenous (IV) conscious sedation for imaging are not eligible; patients requiring mild, oral anxiolytics for the MRI will be allowed to participate as long as the following criteria are met:
* The person has their own prescription for the medication.
* The informed consent process is conducted prior to the self-administration of this medication
* They come to the research visit with a driver
Inclusion Criteria (Participants with CLD):
* Age 7 years or older
* Willing and able to complete study procedures
* Clinical evidence of MASLD, MASH, cirrhosis or liver fibrosis
Exclusion Criteria (Participants with CLD):
* Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
* Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)
* Received ferumoxytol injection within previous one year (clinical or research)
* Patients requiring intravenous (IV) conscious sedation for imaging are not eligible; patients requiring mild, oral anxiolytics for the MRI will be allowed to participate as long as the following criteria are met:
* The person has their own prescription for the medication.
* The informed consent process is conducted prior to the self-administration of this medication
* They come to the research visit with a driver
Inclusion Criteria (Liver Fibrosis Spectrum):
* Age 7 years or older
* Willing and able to complete study procedures
* Known or suspected liver steatosis, steatohepatitis, fibrosis, cirrhosis, or portal hypertension, based on clinical imaging from the previous 6 months or histology over the previous 12 months.
* At least N=50 will be selected based on having a clinically indicated liver biopsy
* If taking beta blocker medication, willing to temporarily discontinue the medication for three days prior to the research visit after providing informed consent and in consultation with their treating physician.
Exclusion Criteria (Liver Fibrosis Spectrum):
* Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
* Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)
* Received ferumoxytol injection within previous one year (clinical or research)
* Patients requiring intravenous (IV) conscious sedation for imaging are not eligible; patients requiring mild, oral anxiolytics for the MRI will be allowed to participate as long as the following criteria are met:
* The person has their own prescription for the medication.
* The informed consent process is conducted prior to the self-administration of this medication
* They come to the research visit with a driver
