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Late-Onset Neonatal Sepsis: A Case-Control Study
Sponsor: Mersin University
Summary
The diagnosis of late-onset sepsis in term neonates has been studied less than that of early-onset sepsis. Procalcitonin (PCT) and C-reactive protein (CRP) are commonly used biomarkers in the diagnosis of sepsis. However, their diagnostic advantage for late-onset sepsis (GNS) is debatable. Rapid and accurate diagnosis of late-onset infection in newborn infants remains a significant goal in clinical practice worldwide. Therefore, the accuracy of diagnostic tests needs to be improved. This study aimed to evaluate the effectiveness of serum biomarkers in the diagnosis and treatment monitoring of late neonatal sepsis (LOS) in term neonates.
Official title: Evaluation of Traditional Biomarkers and Novel Inflammatory Indices in the Diagnosis of Late-Onset Neonatal Sepsis: A Case-Control Study
Key Details
Gender
All
Age Range
3 Days - 28 Days
Study Type
OBSERVATIONAL
Enrollment
128
Start Date
2020-07-01
Completion Date
2025-07-01
Last Updated
2026-06-09
Healthy Volunteers
Yes
Interventions
serum biomarker
that of diagnosis of sepsis, and on the third and seventh days after the commencement of antibiotic therapy. SII was calculated using the formula (neutrophils×platelets)/lymphocytes, and SIAI using neutrophils×monocytes×platelets / lymphocytes
Locations (1)
Mersin University
Mersin, Turkey (Türkiye)