Clinical Research Directory

Inclusion Criteria: 1. Children born between 1 January 2010 and 31 December 2025 with an available neonatal dried blood spot sample collected through the Danish National Newborn Screening Program. 2. Cases: children with verified congenital CMV infection, defined as a positive CMV PCR result on neonatal dried blood spot, blood, or urine collected within the neonatal period. 3. Controls: children without evidence of congenital CMV infection selected from the same newborn screening population and matched to cases on sex, gestational age, birthweight, and age at DBS sampling. Exclusion Criteria: 1. DBS samples not approved for research use. 2. DBS samples with insufficient blood material for RNA expression profiling and/or proteomic analyses. 3. Samples with inadequate analytical quality for molecular or proteomic analyses.