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Effectiveness of Subgingival Instrumentation on Delaying End-stage Renal Diseases Among Chronic Kidney Disease Patients
Sponsor: Postgraduate Institute of Dental Sciences Rohtak
Summary
Chronic kidney disease (CKD) and periodontitis share a bidirectional inflammatory relationship, with cytokines such as IL-6, TNF-α, and hsCRP driving progression in both conditions. Non-surgical periodontal therapy (NSPT) has shown reductions in systemic inflammatory markers with emerging evidence of improved renal function, yet robust Randomized controlled trials targeting pre-dialysis Stage IV-V diabetic CKD patients remain lacking. In the Indian context, where diabetes-related CKD is rapidly rising and access to dialysis is limited, there is a clear lacuna in literature regarding the effectiveness of NSPT in delaying progression to end-stage renal disease. Hence, the present Randomized controlled trial is undertaken to address this gap.
Official title: Effectiveness of Subgingival Instrumentation on Delaying End-stage Renal Diseases Among Chronic Kidney Disease Patients: A Non-Randomized Clinical Study
Key Details
Gender
All
Age Range
40 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-07
Completion Date
2027-12
Last Updated
2026-06-09
Healthy Volunteers
No
Interventions
Subgingival Instrumentation
Participants will receive subgingival instrumentation using an ultrasonic scaler (NSK Variose 2 Ultrasonic Scaler) and hand instruments (Sickle scalers and Curettes, GDC) followed by oral hygiene instructions (OHI).
Oral Hygiene Instructions
Participants will receive basic oral hygiene instructions
Locations (1)
Post Graduate Institute of Dental Sciences , Rohtak
Rohtak, Haryana, India