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BRIDGE-US: Bridging Readiness in Deployed Neurotrauma Gaps for Excellence
Sponsor: University of Chicago
Summary
The purpose of this research study is to prospectively collect biospecimens, imaging, and clinical data from patients with penetrating brain injuries across high-volume PBI sites in the US (including UChicago). Biospecimens will undergo biomarker analysis - biomarker data specific to PBI is extremely limited, and could provide critical insight to outcome identification and clinical decision making. This data will be used to build the first comprehensive PBI Data Commons, biorepository, and imaging repository which will create the infrastructure necessary to close critical knowledge gaps, advance biomarker discovery specific to PBI, and provide the foundation for future research aimed at improving prognostication and treatment for patients with this devastating injury.
Key Details
Gender
All
Age Range
16 Years - Any
Study Type
OBSERVATIONAL
Enrollment
270
Start Date
2026-07-01
Completion Date
2035-12-31
Last Updated
2026-06-09
Healthy Volunteers
No
Interventions
Blood Sample Collection
Subjects with confirmed Penetrating Brain Injury (PBI) will be enrolled upon arrival to each site and have blood samples collected at five timepoints by nurses/phlebotomists/approved research personnel. As soon as possible after injury, preferably within 4 hours of injury, but must be obtained within 8 hours of injury.
Locations (1)
The University of Chicago
Chicago, Illinois, United States