Clinical Research Directory

Inclusion Criteria: 1. CHB patients over 30 years old ； 2. HBV DNA \>20IU/ml and ALT level ≤40U/L； 3. All of them have never received any antiviral treatment(including NAs and interferon-α）。 Exclusion Criteria: 1. pregnancy status; 2. Patients with compensated/decompensated cirrhosis and liver cancer have been diagnosed by imaging or other indicators; 3. HCV, HIV, EB virus/cytomegalovirus infection, schistosomiasis liver disease, drug-induced liver injury, autoimmune hepatitis and alcoholic liver disease; 4. Use immunosuppressants ; 5. Previous history of liver cancer, organ transplantation and alcoholism (male ≥30 g/d, female ≥20 g/d); 6. Insufficient follow-up time and imperfect clinical/laboratory informations; 7. Combined with other major diseases.