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NOT YET RECRUITING
NCT07638189
PHASE2

CBD Knee Osteoarthritis Study

Sponsor: University of Tennessee

View on ClinicalTrials.gov

Summary

Osteoarthritis of the knee is a common cause of pain in the US. The currently available medicines for knee osteoarthritis sometimes are not effective at relieving the pain or have unacceptable side effects. Thus, alternate pain relieving treatments are needed. CBD, an active chemical from the hemp derived cannabis sativa plant, has received a lot of attention for its potential pain relieving properties, but there has been limited research to find out if topically applied CBD can decrease pain from knee osteoarthritis. CBD lacks the psychoactive effects seen with marijuana use, because it does not contain THC which is responsible for those effects in marijuana. It is legal to use CBD in the State of Tennessee (site of study). The CBD Knee Study is sponsored by the University of Tennessee Health Science Center and is a collaborative effort between doctors at UT and Campbell Clinic. In the CBD Knee Study, the investigators are examining whether topically applied CBD dissolved in Castor Oil will relieve knee pain in persons with knee osteoarthritis. Persons who take part in the study would need to come for study visits, fill out questionnaires about their health and knee pain, and would be asked to use the topical study oil on their knees. Taking part in the CBD Knee Study is voluntary.

Official title: Pilot Study Using Topical Cannabidiol (CBD) to Manage Osteoarthritic Knee Pain

Key Details

Gender

All

Age Range

21 Years - Any

Study Type

INTERVENTIONAL

Enrollment

30

Start Date

2026-07-01

Completion Date

2028-03-30

Last Updated

2026-06-10

Healthy Volunteers

No

Conditions

Interventions

DIETARY_SUPPLEMENT

Cannabidiol (CBD)

250 mg of CBD will be dissolved in 1 ml of Castor Oil. Participants will use 1ml of this solution on each knee BID

OTHER

Castor Oil (Placebo)

1 ml of Castor oil alone will be applied to each knee BID as the placebo

Locations (1)

University of Tennessee Health Science Center

Memphis, Tennessee, United States