Clinical Research Directory
Browse clinical research sites, groups, and studies.
Epidemiology of Invasive Bacterial Infections in Children With Sickle Cell Disease in France Between 2020 and 2025
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
Children with sickle cell disease are at high risk of invasive bacterial infections, which may lead to serious complications. Preventive measures, including antibiotic prophylaxis and vaccination, have changed the epidemiology of these infections over time. New pneumococcal conjugate vaccines have recently become available, and updated data are needed to better understand which bacteria are currently responsible for invasive infections in this population. The aim of this retrospective study is to describe the bacterial distribution of invasive bacterial infections in children with sickle cell disease in France between 2020 and 2025. The results may help improve knowledge of these infections and guide future prevention strategies, including antibiotic management and vaccination policies.
Key Details
Gender
All
Age Range
Any - 17 Years
Study Type
OBSERVATIONAL
Enrollment
350
Start Date
2026-07-15
Completion Date
2027-07-15
Last Updated
2026-06-10
Healthy Volunteers
No
Locations (31)
Hôpital Victor Dupouy (CH Argenteuil)
Argenteuil, France
CHI Robert Ballanger
Aulnay-sous-Bois, France
Hôpital Jean Verdier
Bondy, France
Hôpital Pellegrin - Hôpital des Enfants
Bordeaux, France
Hôpital Ambroise Paré
Boulogne-Billancourt, France
Hôpital Saint Camille
Bry-sur-Marne, France
Hôpital NOVO
Cergy-Pontoise, France
Hôpital Antoine Béclère
Clamart, France
CH Sud Francilien
Corbeil-Essonnes, France
CHI Créteil
Créteil, France
CH du Sud Seine et Marne
Fontainebleau, France
CH Gonesse
Gonesse, France
GHEF, Site de Marne-la-Vallée
Jossigny, France
Hôpital Bicêtre
Le Kremlin-Bicêtre, France
GHT Yvelines Nord
Mantes-la-Jolie, France
Hôpital Nord, AP-HM
Marseille, France
GHEF, Site de Meaux
Meaux, France
GH Sud Ile-de-france
Melun, France
GHI Le Raincy-Montfermeil
Montfermeil, France
CHU Nantes
Nantes, France
CH Rives de Seine, Site de Neuilly-sur-Seine
Neuilly-sur-Seine, France
CHU Lenval
Nice, France
Hôpital Paris-Saclay
Orsay, France
Hôpital Necker
Paris, France
Hôpital Robert Debré
Paris, France
Hôpital Trousseau
Paris, France
CHI Poissy
Poissy, France
CH Rambouillet
Rambouillet, France
CH Saint Denis, Hôpital Delafontaine
Saint-Denis, France
Hôpital André Mignot
Versailles, France
Hôpital Intercommunal Villeneuve-St-Georges
Villeneuve-Saint-Georges, France