Clinical Research Directory

Inclusion Criteria: * Skin type origin: Asian in China * Age: from 40 to 65 years old * Gender: female * Specific criteria: • All skin type on the face Dry, dry combination, normal 1. presenting with a lack of elasticity to the face, inclusion grade ≤ 6 according 10 points scale 2. presenting with a lack of density to the face, inclusion grade ≤ 6 according 10 points scale 3. presenting with wrinkles on crow's feet area, grade ≥ 2 according to Skin ageing atlas Vol.2 (p.41) 4. presenting with pigmentary spots with at least one with diameter ≥ 3mm * Usual or occasional user of food supplements * Able to give her informed consent Exclusion Criteria: The non-inclusion general criteria were the following ones: * allergies or reactivity to cosmetic products, * for the subjects undergoing hormonal treatment; change of treatment within 3 months preceding the inclusion visit, * expectation of change in the current hormonal treatment during the study, * anti-allergic, antibiotic, anti-inflammatory, dermatological treatment or corticosteroid therapy within 2 weeks before the inclusion visit, * having a chronic pathology, * performing or prevision to perform another test during the study or during the exclusion period, * employee of the COSderma laboratory, * pregnant or breast-feeding woman, * woman not taking precaution to prevent pregnancy. The non-inclusion specific criteria were the following ones: * application of care products to the face within 48 hours preceding the inclusion visit, * application of make-up products to the face the day of the inclusion visit, * face wash with any other means than clear water (no soap or cleanser) on the day of the inclusion visit, * application of self-tanning products to the face within 4 weeks preceding the inclusion visit, * Oral intake of food supplement within 1 month preceding the inclusion visit, * cutaneous marks on the face which could interfere with the skin's clinical signs assessment (pigmentation issues, scar tissues, over-developed hairiness, too many ephelides and naevi, sunburns...), * solar exposition (natural sun or UVA or heliotherapy treatment) within 4 weeks preceding the inclusion visit and expectation of solar exposition (natural or UVA) during the study, * Vitamin A acid treatment or its derivatives within 3 months preceding the pre-inclusion visit, * Retinoid based oral treatment within 6 months before the pre-inclusion visit, or local treatment within 2 months prior to this visit, * Carotene based treatment within 4 weeks preceding the inclusion visit, * expectation or having undergone aesthetic or dermatological surgery on the face.