Clinical Research Directory

Inclusion Criteria: * Male or female subjects aged 18 to 65 years (inclusive) * Provided written informed consent prior to participation * Able to brush their own teeth on a daily basis * In good general health based on medical history review * Minimum of at least 18 natural, scorable teeth * Mean plaque index score ≥ 1.95 * Mean baseline gingival index score ≥ 1.70 and ≤ 3.0 * Agreed to refrain from use of all oral hygiene products other than those supplied for the study * Agreed to refrain from oral hygiene, eating, drinking, and chewing gum for approximately 12 hours prior to study visits * Agreed not to undergo dental prophylaxis or elective dental procedures during the study * Willing and able to comply with study procedures and visit schedule Exclusion Criteria: * Physical limitations or restrictions that preclude normal tooth brushing * Requirement for premedication prior to dental treatment * Pregnancy or intent to become pregnant during the study period * Use of tobacco or nicotine products * Poor oral hygiene defined as \>40 bleeding sites * Presence of dental caries or calculus deposits that may interfere with plaque assessments * Major oral hard or soft tissue lesions or trauma at baseline * Presence of fixed or removable orthodontic appliances * Dental prophylaxis within 1 month prior to baseline visit * History of significant adverse events, allergy, or irritation related to oral hygiene products