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Investigation of Pain Modulation Phenotypes in Female Patients With Fibromyalgia
Sponsor: Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Summary
Fibromyalgia is characterized by altered pain processing, including impaired descending pain inhibition and central sensitization. While both mechanisms have been independently associated with disease severity, their interrelationship remains unclear. This cross-sectional study aims to investigate whether central sensitization symptoms mediate the relationship between conditioned pain modulation and fibromyalgia impact.
Key Details
Gender
FEMALE
Age Range
18 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
82
Start Date
2026-07-01
Completion Date
2026-09-01
Last Updated
2026-07-07
Healthy Volunteers
No
Conditions
Interventions
Quantitative Sensory Tests(QST) protocol
including PPT Measurement with an Algometer, CPM and the Slow-Repeated Stimulated Pain Assessment Protocol
Clinical Scales
Central Sensitization Inventory, Revised Fibromyalgia Impact Questionnaire, S-LANSS, Tampa Kinesiophobia Scale, Hospital Anxiety and Depression Scale, SF-12 Quality of Life Scale and Fatigue Severity Scale