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Reperfusion Approach in Predicted In-hospital Delay for Primary PCI in STEMI
Sponsor: National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Summary
This study aims at evaluating of the effectiveness of in-hospital thrombolysis for ST-segment elevation myocardial infarction in PCI centers under conditions of predicted in-hospital delay (\>60 min after admission in PCI-center) of PCI. Following randomisation a strategy of early tenecteplase and additional antiplatelet and antithrombin therapy followed by catheterisation within 2-24 hours with timely coronary intervention as appropriate (or by rescue coronary intervention if required) in Group A will be compared to primary PCI performed according to local standards in Group B.
Official title: A Randomized Controlled Study of Reperfusion Strategies in Acute ST-segment Elevation Myocardial Infarction Under Conditions of Anticipated In-hospital Delay in Primary Percutaneous Coronary Intervention Strategy: the Reperfusion Approach in Predicted In-hospital Delay for Primary PCI in STEMI (RAPID-STEMI)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
240
Start Date
2026-05-20
Completion Date
2029-05-20
Last Updated
2026-06-11
Healthy Volunteers
No
Interventions
Single, weight-adjusted i.v. bolus of tenecteplase
Single, weight-adjusted i.v. bolus of tenecteplase in case of \>60 min in-hospital delay in PCI center
catheterisation
Standard primary PCI
Locations (1)
National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Moscow, Select A State, Russia