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Prediction of Atrial Fibrillation Using Polygenic Risk Score
Sponsor: Seoul St. Mary's Hospital
Summary
The goal of this clinical trial is to learn whether a genetic risk score can help identify undiagnosed atrial fibrillation (AF) in adults who may have it. AF is an irregular heartbeat that raises the risk of stroke if not treated early. The main questions it aims to answer are: Can a polygenic risk score (PRS) - a score based on a person's genes - identify who is more likely to have AF? Does combining PRS with a person's medical history predict AF better than using medical history alone? Participants will: Wear a continuous ECG patch for 7 days to record heart rhythm Give a blood sample for genetic testing to calculate their PRS Use a six-lead handheld ECG device (HATIV® P30, VUNO Inc., Seoul, Republic of Korea) to check their own heart rhythm at home once or twice a week for 1 year Visit the clinic 5 times over 1 year Researchers will use the genetic and clinical information collected to build a scoring system that predicts who is at risk for AF.
Official title: Development of an Atrial Fibrillation Prediction Model Using Polygenic Risk Score: A Prospective Cohort Study
Key Details
Gender
All
Age Range
20 Years - 79 Years
Study Type
INTERVENTIONAL
Enrollment
800
Start Date
2024-11-19
Completion Date
2027-06-30
Last Updated
2026-06-11
Healthy Volunteers
No
Conditions
Interventions
7-day continuous ECG patch monitor
Continuous ECG patch worn for 7 days at enrollment to detect atrial fibrillation and other arrhythmias.
Six-lead handheld electrocardiogram device
Six-lead ECG device used for self-monitoring at least once or twice weekly and upon symptoms for 1 year.
SNP array genotyping
DNA extracted from a 5cc blood sample is used to perform SNP array genotyping. The resulting data are used to calculate a polygenic risk score (PRS) for atrial fibrillation based on previously published genome-wide association study results.
Locations (5)
The Catholic University of Korea Incheon St. Mary's Hospital
Incheon, South Korea
The Catholic University of Korea Seoul St. Mary's Hospital
Seoul, South Korea
The Catholic University of Korea Eunpyeong St. Mary's Hospital
Seoul, South Korea
The Catholic University of Korea St. Vincent's Hospital
Suwon, South Korea
The Catholic University of Korea Uijeongbu St. Mary's Hospital
Uijeongbu-si, South Korea