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CleaRRAflow: Isotonic Solution vs. TPA for IVH Clearance
Sponsor: David Dornbos
Summary
The study aims to investigate the effect of continuous tPA irrigation into the ventricles. Investigators believe it may be superior to the traditional every 8-hour bolus dosing and continuous isotonic solution irrigation alone. The protocol plans to analyze blood clearance and functional outcomes in the patients.
Official title: Utility of Continuous Intrathecal TPA Infusion for IVH Clearance With Ventricular Irrigation
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-06-01
Completion Date
2029-05-31
Last Updated
2026-06-11
Healthy Volunteers
No
Interventions
Tissue Plasminogen Activator (tPA)
Tissue Plasminogen Activator (tPA) is infused through the ClearRRAflow catheter into the ventricular system to promote clearance of intraventricular hemorrhage.
Isotonic solution
Isotonic solution irrigation delivered through the CleaRRAflow catheter into the ventricular system to promote intraventricular hemorrhage clearance.
Locations (1)
UKHC
Lexington, Kentucky, United States