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Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Fracture Surgery
Sponsor: Peking University First Hospital
Summary
Older patients with hip fractures often suffer from severe pain. Inadequate analgesia increases the risk of postoperative delirium, myocardial injury, and other complications. Peripheral nerve block is an important component of multimodal analgesia, but conventional local anesthetics (e.g., plain bupivacaine) provide only approximately 12 hours of analgesic duration, which is far from covering the most painful 72 hours after surgery. Liposomal bupivacaine has a slow-release property, prolonging the analgesic duration up to 72 hours after a single injection. However, its clinical advantages in hip fracture surgery remain controversial. The investigators suppose that, compared with plain bupivacaine alone, preoperative supra-inguinal fascia iliaca block using liposomal bupivacaine combined with plain bupivacaine can further improve analgesia within 72 hours after surgery in older patients undergoing hip fracture surgery, decrease opioid consumption, and improve postoperative recovery quality.
Official title: Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Fracture Surgery: a Randomized Trial
Key Details
Gender
All
Age Range
55 Years - Any
Study Type
INTERVENTIONAL
Enrollment
148
Start Date
2026-07
Completion Date
2028-08
Last Updated
2026-06-12
Healthy Volunteers
No
Conditions
Interventions
Liposomal bupivacaine (LB)
A single preoperative ultrasound-guided supra-inguinal fascia iliaca block will be perfomed using a mixture of 10 mL of 0.5% plain bupivacaine plus 20 mL of liposomal bupivacaine (266 mg), total volume 30 mL. The mixture will be injected after negative aspiration and under real-time ultrasound visualization to confirm correct needle tip placement between the fascia iliaca and the iliacus muscle. The block will be performed in the preoperative holding area.
Plain bupivacaine
A single preoperative ultrasound-guided supra-inguinal fascia iliaca block will be performed using 30 mL of 0.5% plain bupivacaine (150 mg). The injection will be performed after negative aspiration and under real-time ultrasound guidance to ensure proper spread between the fascia iliaca and the iliacus muscle. The block is performed in the preoperative holding area.
Locations (1)
Peking University First Hospital
Beijing, Beijing Municipality, China