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Kynurenic Acid and Serotonin as Perioperative Neuroinflammatory Biomarkers in Sequential Third Molar Surgery
Sponsor: Plovdiv Medical University
Summary
A prospective cohort of 40 consecutive patients with bilateral impacted mandibular third molars underwent two sequential surgical extractions separated by a two-week interval. Serum kynurenic acid (KYNA) and serotonin were measured preoperatively and 24 hours after each procedure. The study examined longitudinal dynamics of kynurenine pathway biomarkers, their variation across Pederson surgical difficulty grades, and their relationship with postoperative pain and state anxiety.
Official title: Influence of Serotonin and Kynurenic Acid on Postoperative Pain, Neuroinflammation and Anxiety Following Surgical Removal of Impacted Mandibular Third Molars
Key Details
Gender
All
Age Range
18 Years - 38 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2017-10-16
Completion Date
2020-09-30
Last Updated
2026-09-21
Healthy Volunteers
Yes
Interventions
Placebo
Identical-appearing oral capsules administered preemptively 1 hour before incision and every 8 hours for 24 hours.
Ibuprofen
Ibuprofen 400 mg oral capsules administered preemptively 1 hour before incision and every 8 hours for 24 hours.
Ibuprofen + Gabapentin
Ibuprofen 400 mg plus Gabapentin 300 mg oral capsules administered preemptively 1 hour before incision and every 8 hours for 24 hours.
Locations (1)
Faculty of Dental Medicine
Plovdiv, Plovdiv, Bulgaria