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Individualizing Anti-TNF Therapy in Patients With Inflammatory Bowel Disease
Sponsor: Shmuel Kivity, MD
Summary
This observational study aims to identify genes that may affect how patients with inflammatory bowel disease respond to anti-TNF treatment and why some patients lose response to treatment over time. The study will examine whether genetic markers can help predict which patients are more likely to respond to anti-TNF therapy. Participants who have not previously received anti-TNF treatment and are about to start advanced therapy will provide a blood sample to test for the genetic markers. Participants will also undergo regular assessments of current treatment, disease activity, and inflammatory markers during follow-up.
Official title: Individualizing Anti-TNF Therapy in Patients With Inflammatory Bowel Disease: Pre-Treatment Prediction of Immunogenicity and Response. A Prospective Observational Study.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2025-01-04
Completion Date
2028-12
Last Updated
2026-06-12
Healthy Volunteers
No
Interventions
This is an observational study with no intervention. Patients will receive anti- TNF therapy as part of their standard care
Patients will receive therapy as part of their standard care according to the standard dose
Locations (1)
Dep. of Gastroenterology, Tel Aviv Sourasky Medical Center
Tel Aviv, Israel