Clinical Research Directory

Inclusion Criteria: * Age 18 or older * Any patient undergoing elective hand surgery Exclusion Criteria: * Any patient with a traumatic or infected open wound (only surgically created wounds will be included) * History of chronic pain * History of narcotic addiction * History of recreational drug dependency * History of psychiatric pathology * Allergy or hypersensitivity to local anesthetics, recombinant human thrombin or tranexamic acid * History of coagulopathy or active thromboembolic disease * Any patient receiving a supra/infraclavicular block for anesthesia * Pregnancy * Hypersensitivity to hamster proteins * History of seizures * Significant renal impairment (chronic kidney disease stage 3 or greater) * History of retinal vascular disease or history of unexplained visual symptoms * Active upper urinary tract bleeding * History of known hypercoagulable disorder, prior thromboembolic events, or active clotting disorders * History of severe hepatic dysfunction (active hepatitis or steatohepatitis, hepatic fibrosis considered cirrhosis)