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Body Weight Reduction and Metabolic/Biochemical Parameters in Overweight or Obesity
Sponsor: Medical University of Silesia
Summary
This was a single-center prospective observational cohort study conducted in Poland in the context of routine metabolic outpatient care. The study assessed selected metabolic, biochemical, oxidative-stress, inflammatory, and body-composition parameters in individuals with overweight or obesity undergoing standard lifestyle-based body weight reduction management. Participants with BMI \> 25 kg/m² were followed before and after body weight reduction, while individuals with normal body weight served as a comparison group. The weight reduction management included individualized dietary recommendations, physical-activity guidance, health education, regular follow-up visits, fasting blood sampling, and body-composition assessment. The aim of the study was to evaluate whether body weight reduction is associated with changes in metabolic and biochemical parameters, with particular attention to glucose and lipid metabolism, oxidative stress, inflammatory markers, adipokines, cytokines, and body-composition changes.
Official title: The Effect of Body Weight Reduction on Selected Metabolic and Biochemical Parameters in Individuals With Overweight or Obesity
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
OBSERVATIONAL
Enrollment
53
Start Date
2016-05-10
Completion Date
2022-09-30
Last Updated
2026-06-12
Healthy Volunteers
No
Interventions
Routine Lifestyle-Based Weight Reduction Management
Standard lifestyle-based body weight reduction management received as part of routine metabolic outpatient care. It included individualized dietary recommendations, physical-activity guidance, health education, and regular follow-up visits. Participants were not assigned to this management as part of the study; the study prospectively observed patients receiving routine care and assessed metabolic, biochemical, inflammatory, oxidative-stress, adipokine, cytokine, and body-composition parameters before and after body weight reduction.
Locations (2)
Eko-Prof-Med Medical Center, Metabolic Outpatient Clinic
Miasteczko Śląskie, Silesian Voivodeship, Poland
Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice
Zabrze, Silesian Voivodeship, Poland