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SBRT-LATTICE-PATHY
Sponsor: University of Sao Paulo General Hospital
Summary
To assess the importance of using SBRT-LATTICE-PATHY for the radiotherapy treatment of large tumors that would be considered intractable by currently used standard techniques. In this present study, the investigators will have the possibility of combining SBRT and LATTICE techniques, incorporating the concept of hypoxic tissue irradiation, which are potential modulators of abscopal and bystander effects, performing partial punctual treatment in the vertex region, without the need for irradiation of the entire tissue volume, further improving safety in relation to possible toxicities.
Official title: Impact of Partial Stereotactic Body Radiotherapy in Hypoxic Segments of Large-volume Unresectable Tumors (SBRT-LATTICE-PATHY) - a Prospective Phase II Study.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2026-04-28
Completion Date
2027-12-31
Last Updated
2026-06-12
Healthy Volunteers
No
Interventions
SBRT-LATTICE-PATHY
SBRT-LATTICE-PATHY, a single dose of 24Gy in intratumoral vertices located in hypoxic regions.
Locations (1)
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - Instituto de Radiologia
São Paulo, São Paulo, Brazil