Inclusion Criteria:
* Voluntary participation, signing a written informed consent form;
* The age on the date of signing the informed consent form should be no less than 18 years old, regardless of gender;
* The subjects have completed the standard TURBT procedure before signing the informed consent form, and no obvious residual tumor lesions were found in the surgical field;
* The postoperative pathology clearly diagnosed as non-muscle-invasive bladder cancer, and the main tissue component was more than 50% urothelial carcinoma (transitional cell carcinoma);
* The subjects were classified into the intermediate-risk or high-risk group according to the risk classification for NMIBC;
* Tumor tissue samples for TURBT must be provided, along with the required relevant pathological reports. Fresh surgical tissues or pathological slides can be sent for examination as well;
* The patients were intolerant to BCG or did not accept the BCG infusion treatment plan;
* Before treatment, HER2 detection was conducted on the resection specimens in the laboratory: The IHC results confirmed HER2 expression (defined as: IHC 1+, 2+ or 3+);
* Clinical non-metastatic bladder cancer (N0, M0) was determined by abdominal computed tomography (CT).
Exclusion Criteria:
* History of muscle-invasive bladder cancer or metastatic bladder cancer before treatment;History of muscle-invasive bladder cancer or metastatic bladder cancer before treatment;
* Imaging results within 3 months before treatment indicated lymph node or other site/organ metastasis;
* Imaging results within 3 months before treatment indicated the presence of other urinary system tumors;
* Received other systemic anti-cancer treatments within 3 weeks before treatment, including chemotherapy, biological therapy, immunotherapy, targeted therapy, endocrine therapy, and/or investigational drug therapy;
* Received bladder radiotherapy for urothelial carcinoma before treatment;
* Known to have anaphylaxis or delayed allergic reaction to certain components of vedacitinib or similar drugs;
* Within the 3 days prior to the first infusion, the following conditions had not yet been alleviated to CTCAE grade 1:Uncontrolled acute or chronic infections, such as pneumonia, biliary tract infections;Hepatitis B and Hepatitis C infections; dyspnea;Acute or chronic kidney injury; nephrotic syndrome; bladder perforation; urinary tract obstruction;
* NYHA rating of 3 or 4;
* Symptoms and signs related to cardiovascular diseases: including myocardial infarction, congestive heart failure, arrhythmia, etc.;
* Known cerebrovascular accidents;
* History of autoimmune diseases (such as inflammatory bowel disease, idiopathic thrombocytopenic purpura, systemic lupus erythematosus, hemolytic anemia, rheumatoid arthritis, etc.);
* Known positive HIV serology, Hepatitis C infection and/or Hepatitis B (HepBsAg or core antibody positive and responding after antiviral treatment for Hepatitis B, except for these patients: these patients are allowed to participate in this study; Note: Patients with negative HepBsAg at screening)
