Clinical Research Directory

Inclusion Criteria: * Males and females aged over 18 years. * Informing the patient in writing about the inclusion in the study and his/her consent to participate in it. * Absence of conditions requiring urgent medical care. * The patient was diagnosed with chronic hemorrhoids of grade 2 or 3 according to Goligher classification. * The patient is scheduled to undergo one of the listed types of minimally invasive surgical treatment within 7 ± 2 days from the inclusion in the study (V0): * laser vaporization (laser submucosal destruction or ablation); * transanal dearterialization (hemorrhoidal artery ligation); * transanal dearterialization + laser vaporization (laser submucosal destruction or ablation); * transanal dearterialization + sclerotherapy. * No venoactive drug treatment within 4 weeks prior to inclusion in the study. * The patient has been prescribed with MPFF at the inclusion visit, or it is planned to prescribe MPFF-containing drug in the postoperative period (for cluster 1 sites), or the patient has not been prescribed with any systemic venoactive drug, and it is not planned to prescribe it the postoperative period (for cluster 2 sites).\* Exclusion Criteria: * Pregnancy or breast-feeding, or planning for pregnancy during the study or at least in two months after its completion. * Confirmed or suspected malignancy. * Severe somatic disorder (of heart or blood vessels, lungs, kidneys, pancreas, or liver), accompanied by the organ function decompensation. * Mental disorder. * Contraindications for examination. * Predicted unwillingness of the patient to follow the protocol of treatment and supervision, poor adherence to treatment. * Patient's participation in any interventional/observational study at the present time. * Patients who received venoactive drugs in the 4 weeks prior to Visit 0 (inclusion visit).