Clinical Research Directory

Inclusion Criteria: Age ≥18 years Diagnosis of pancreatic cancer that is potentially resectable per the treating clinical team's assessment. Planned to receive or actively receiving neoadjuvant chemotherapy prior to surgery. Frail or pre-frail as defined by the protocol-specified frailty assessment tool (e.g., Fried Frailty Phenotype; pre-frail = 1-2 criteria; frail =\> 3 criteria). Able to provide written informed consent. Medically appropriate to participate in supervised, symptom-limited exercise as determined by study screening and, if indicated, the treating clinician's input. Able to complete study assessments and questionnaires in English or Spanish (using IRB-approved instruments/materials). Exclusion Criteria: Adults unable to consent. Medical condition that, in the judgment of the investigator and/or treating clinician, makes exercise unsafe (e.g., unstable angina, uncontrolled arrhythmia, decompensated heart failure, uncontrolled severe pulmonary disease). Any absolute contraindication to exercise participation/testing per institutional standards. Severe symptoms or functional impairment that prevents safe participation despite program modification. Inability to comply with the intervention schedule and study procedures despite reasonable scheduling accommodations.